ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION

The aspects of autoimmune thyroiditis (AIT) remain quite actual, since many issues of etiology, pathogenesis, morphology, classification, diagnostics, therapy and prediction of this disorder are far from final solution. Since disturbances of fine molecular immune mechanisms underlie pathogenesis of...

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Autores principales:	E. M. Biktagirova, O. A. Kravtsova, L. I. Sattarova, G. R. Vagapova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoimmune thyroiditis protein tyrosine phosphatase сtla gene Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6288f18568884c7b80e4d86f651dc479
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spelling	oai:doaj.org-article:6288f18568884c7b80e4d86f651dc4792021-11-18T08:03:37ZASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION1563-06252313-741X10.15789/1563-0625-2010-1-2-103-114https://doaj.org/article/6288f18568884c7b80e4d86f651dc4792014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/51https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aspects of autoimmune thyroiditis (AIT) remain quite actual, since many issues of etiology, pathogenesis, morphology, classification, diagnostics, therapy and prediction of this disorder are far from final solution. Since disturbances of fine molecular immune mechanisms underlie pathogenesis of either immune disorder, the genes coding its main components, are regarded as potential candidate genes predisposing for AIT, e.g., genes of surface antigen (CTLA-4) and protein tyrosine phosphatase non-receptor 22 (PTPN-22). We have performed genotyping of 298 Tatar women in Tatar Republic (Russia) with respect to age and biochemical parameters (control group, 137 persons; AIT group, 161 patients). The following gene polymorphisms were tested: +49 А/G, -318 С/Т, -1661 А/G of СТLA-4 gene, and 1858 С/Т polymorphism of PTPN-22 gene. Genotyрing was performed by PCR-RFLP method as described earlier. The data were analyzed using Chi-square test and 95% confidential interval (CI). The frequencies of CTLA-4 -1661 G allele and genotype A/G and +49 G/A G allele and genotype GG carriers were significantly higher in AIT patients than in controls (P = 0.04, OR 1.84, 95% CI 2.31-1.4; P = 0.001, OR 2,0 95% CI 1.62-2.31 respectively), with increased contents of serum antibodies to thyroglobulin (OR, 1.56, 95% CI 2.25-3.6; OR 1.12, 95% CI 1.9-2.75, respectively) and to thyroperoxidase (OR 1.3, 95% CI 1.5-4.1 for G/G genotype of +49 A/G polymorphism), independently of age (р < 0,05). We showed that the combinations of A/G, T/C and G/G genotypes of -1661 A/G, -318 T/C and +49 G/A polymorphisms is associated with increased risk of genetic predisposition to ITD in Tatar women (OR 7.87, 95% CI 2.03-3.25). A strong association was also observed between the increased level of antibodies to TPO (> 1000 ME/l) and GG genotype of +49 G/A polymorphism (OR 1.3, 95% CI 1.5-4.1) and antibodies to TG (> 100 ME/l) and genotypes A/G and G/G of CTLA-4 -1661 A/G and +49 G/A polymorphisms (OR 1.56, 95% CI 2.25-3.6; OR 1.12, 95% CI 1.9-2.75, respectively), independently of age. The genotypes -318 T/C and 1858 T/C of CTLA-4 and PTPN-22 genes, respectively, are not associated with AITD in Tatar women (p > 0.05). Our results suggest that polymorphisms of CTLA-4 and PTPN-22 genes may modify individual susceptibility to autoimmune thyroiditis in Tatar women.E. M. BiktagirovaO. A. KravtsovaL. I. SattarovaG. R. VagapovaSPb RAACIarticleautoimmune thyroiditisprotein tyrosine phosphataseсtla geneImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 103-114 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoimmune thyroiditis protein tyrosine phosphatase сtla gene Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmune thyroiditis protein tyrosine phosphatase сtla gene Immunologic diseases. Allergy RC581-607 E. M. Biktagirova O. A. Kravtsova L. I. Sattarova G. R. Vagapova ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION
description	The aspects of autoimmune thyroiditis (AIT) remain quite actual, since many issues of etiology, pathogenesis, morphology, classification, diagnostics, therapy and prediction of this disorder are far from final solution. Since disturbances of fine molecular immune mechanisms underlie pathogenesis of either immune disorder, the genes coding its main components, are regarded as potential candidate genes predisposing for AIT, e.g., genes of surface antigen (CTLA-4) and protein tyrosine phosphatase non-receptor 22 (PTPN-22). We have performed genotyping of 298 Tatar women in Tatar Republic (Russia) with respect to age and biochemical parameters (control group, 137 persons; AIT group, 161 patients). The following gene polymorphisms were tested: +49 А/G, -318 С/Т, -1661 А/G of СТLA-4 gene, and 1858 С/Т polymorphism of PTPN-22 gene. Genotyрing was performed by PCR-RFLP method as described earlier. The data were analyzed using Chi-square test and 95% confidential interval (CI). The frequencies of CTLA-4 -1661 G allele and genotype A/G and +49 G/A G allele and genotype GG carriers were significantly higher in AIT patients than in controls (P = 0.04, OR 1.84, 95% CI 2.31-1.4; P = 0.001, OR 2,0 95% CI 1.62-2.31 respectively), with increased contents of serum antibodies to thyroglobulin (OR, 1.56, 95% CI 2.25-3.6; OR 1.12, 95% CI 1.9-2.75, respectively) and to thyroperoxidase (OR 1.3, 95% CI 1.5-4.1 for G/G genotype of +49 A/G polymorphism), independently of age (р < 0,05). We showed that the combinations of A/G, T/C and G/G genotypes of -1661 A/G, -318 T/C and +49 G/A polymorphisms is associated with increased risk of genetic predisposition to ITD in Tatar women (OR 7.87, 95% CI 2.03-3.25). A strong association was also observed between the increased level of antibodies to TPO (> 1000 ME/l) and GG genotype of +49 G/A polymorphism (OR 1.3, 95% CI 1.5-4.1) and antibodies to TG (> 100 ME/l) and genotypes A/G and G/G of CTLA-4 -1661 A/G and +49 G/A polymorphisms (OR 1.56, 95% CI 2.25-3.6; OR 1.12, 95% CI 1.9-2.75, respectively), independently of age. The genotypes -318 T/C and 1858 T/C of CTLA-4 and PTPN-22 genes, respectively, are not associated with AITD in Tatar women (p > 0.05). Our results suggest that polymorphisms of CTLA-4 and PTPN-22 genes may modify individual susceptibility to autoimmune thyroiditis in Tatar women.
format	article
author	E. M. Biktagirova O. A. Kravtsova L. I. Sattarova G. R. Vagapova
author_facet	E. M. Biktagirova O. A. Kravtsova L. I. Sattarova G. R. Vagapova
author_sort	E. M. Biktagirova
title	ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION
title_short	ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION
title_full	ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION
title_fullStr	ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION
title_full_unstemmed	ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION
title_sort	association of ctla-4 and ptpn-22 genes polymorphisms with increased risk of autoimmune thyroiditis in tatar population
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/6288f18568884c7b80e4d86f651dc479
work_keys_str_mv	AT embiktagirova associationofctla4andptpn22genespolymorphismswithincreasedriskofautoimmunethyroiditisintatarpopulation AT oakravtsova associationofctla4andptpn22genespolymorphismswithincreasedriskofautoimmunethyroiditisintatarpopulation AT lisattarova associationofctla4andptpn22genespolymorphismswithincreasedriskofautoimmunethyroiditisintatarpopulation AT grvagapova associationofctla4andptpn22genespolymorphismswithincreasedriskofautoimmunethyroiditisintatarpopulation
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ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION

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