Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study

BackgroundMild cognitive impairment (MCI) is a transitional state between normal elderly people and dementia, with a higher risk of dementia transition. The primary purpose of the current study was to investigate whether routine blood and blood biochemical markers could be used to predict the onset...

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Autores principales:	Wei Li, Ling Yue, Lin Sun, Shifu Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fasting plasma glucose MCI cross-sectional elderly Chinese Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/628a7a00beea4cfaa718dce77132bbd2
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spelling	oai:doaj.org-article:628a7a00beea4cfaa718dce77132bbd22021-11-16T06:57:00ZElevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study1664-239210.3389/fendo.2021.739257https://doaj.org/article/628a7a00beea4cfaa718dce77132bbd22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.739257/fullhttps://doaj.org/toc/1664-2392BackgroundMild cognitive impairment (MCI) is a transitional state between normal elderly people and dementia, with a higher risk of dementia transition. The primary purpose of the current study was to investigate whether routine blood and blood biochemical markers could be used to predict the onset of MCI.MethodsData was obtained from the cohort study on brain health of the elderly in Shanghai. A total of 1015 community elders were included in the current study. Based on clinical evaluation and the scores of Montreal Cognitive Assessment (MoCA), these participants were divided into the MCI (n=444) and cognitively normal groups (n=571). Then we tested their fasting blood routine and blood biochemical indexes, and collected their general demographic data by using a standard questionnaire.ResultsBy using binary logistic regression analysis and the ROC curve, we found that elevated fasting plasma glucose (p=0.025, OR=1.118, OR=1.014-1.233) was a risk factor for MCI.ConclusionsElevated fasting blood glucose may be a risk factor for mild cognitive impairment, but the above conclusions need to be verified by longitudinal studies.Wei LiWei LiLing YueLing YueLin SunLin SunShifu XiaoShifu XiaoFrontiers Media S.A.articlefasting plasma glucoseMCIcross-sectionalelderlyChineseDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fasting plasma glucose MCI cross-sectional elderly Chinese Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	fasting plasma glucose MCI cross-sectional elderly Chinese Diseases of the endocrine glands. Clinical endocrinology RC648-665 Wei Li Wei Li Ling Yue Ling Yue Lin Sun Lin Sun Shifu Xiao Shifu Xiao Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study
description	BackgroundMild cognitive impairment (MCI) is a transitional state between normal elderly people and dementia, with a higher risk of dementia transition. The primary purpose of the current study was to investigate whether routine blood and blood biochemical markers could be used to predict the onset of MCI.MethodsData was obtained from the cohort study on brain health of the elderly in Shanghai. A total of 1015 community elders were included in the current study. Based on clinical evaluation and the scores of Montreal Cognitive Assessment (MoCA), these participants were divided into the MCI (n=444) and cognitively normal groups (n=571). Then we tested their fasting blood routine and blood biochemical indexes, and collected their general demographic data by using a standard questionnaire.ResultsBy using binary logistic regression analysis and the ROC curve, we found that elevated fasting plasma glucose (p=0.025, OR=1.118, OR=1.014-1.233) was a risk factor for MCI.ConclusionsElevated fasting blood glucose may be a risk factor for mild cognitive impairment, but the above conclusions need to be verified by longitudinal studies.
format	article
author	Wei Li Wei Li Ling Yue Ling Yue Lin Sun Lin Sun Shifu Xiao Shifu Xiao
author_facet	Wei Li Wei Li Ling Yue Ling Yue Lin Sun Lin Sun Shifu Xiao Shifu Xiao
author_sort	Wei Li
title	Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study
title_short	Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study
title_full	Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study
title_fullStr	Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study
title_full_unstemmed	Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study
title_sort	elevated fasting plasma glucose is associated with an increased risk of mci: a community-based cross-sectional study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/628a7a00beea4cfaa718dce77132bbd2
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Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study

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