Increased risk of major depressive disorder in sleep apnea patients in Taiwan

Abstract The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this population-based cohort study to asse...

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Autores principales:	Chia-Min Chen, Chia-Yu Kuo, Meng-Ni Wu, Jen-Yu Hung, Chung-Yao Hsu, Ming-Ju Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6290628cee2c41d9a2844b9c6db6053b
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spelling	oai:doaj.org-article:6290628cee2c41d9a2844b9c6db6053b2021-12-02T14:02:34ZIncreased risk of major depressive disorder in sleep apnea patients in Taiwan10.1038/s41598-020-80759-32045-2322https://doaj.org/article/6290628cee2c41d9a2844b9c6db6053b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80759-3https://doaj.org/toc/2045-2322Abstract The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this population-based cohort study to assess the association between SA and MDD. We identified adult patients having SA from the Taiwan National Health Insurance Research Database and excluded those having MDD before SA diagnosis. Thirty control subjects were randomly selected to match to each SA patient by age and sex. Totally, 10,259 SA patients were matched to 102,590 control subjects. The incidence rate and cumulative incidence of MDD were significantly higher in SA patients than in the control subjects (both p < 0.0001). Multivariable Cox regression analysis showed that SA remained an independent risk factor for incident MDD after adjusting for age, sex, residency, income level, and comorbidities (hazard ratio = 2.9 [95% CI 2.8–3.1], p < 0.0001). In summary, SA patients have an increased risk to develop MDD. Physicians caring for SA patients must pay attention to their psychosocial health status.Chia-Min ChenChia-Yu KuoMeng-Ni WuJen-Yu HungChung-Yao HsuMing-Ju TsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Min Chen Chia-Yu Kuo Meng-Ni Wu Jen-Yu Hung Chung-Yao Hsu Ming-Ju Tsai Increased risk of major depressive disorder in sleep apnea patients in Taiwan
description	Abstract The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this population-based cohort study to assess the association between SA and MDD. We identified adult patients having SA from the Taiwan National Health Insurance Research Database and excluded those having MDD before SA diagnosis. Thirty control subjects were randomly selected to match to each SA patient by age and sex. Totally, 10,259 SA patients were matched to 102,590 control subjects. The incidence rate and cumulative incidence of MDD were significantly higher in SA patients than in the control subjects (both p < 0.0001). Multivariable Cox regression analysis showed that SA remained an independent risk factor for incident MDD after adjusting for age, sex, residency, income level, and comorbidities (hazard ratio = 2.9 [95% CI 2.8–3.1], p < 0.0001). In summary, SA patients have an increased risk to develop MDD. Physicians caring for SA patients must pay attention to their psychosocial health status.
format	article
author	Chia-Min Chen Chia-Yu Kuo Meng-Ni Wu Jen-Yu Hung Chung-Yao Hsu Ming-Ju Tsai
author_facet	Chia-Min Chen Chia-Yu Kuo Meng-Ni Wu Jen-Yu Hung Chung-Yao Hsu Ming-Ju Tsai
author_sort	Chia-Min Chen
title	Increased risk of major depressive disorder in sleep apnea patients in Taiwan
title_short	Increased risk of major depressive disorder in sleep apnea patients in Taiwan
title_full	Increased risk of major depressive disorder in sleep apnea patients in Taiwan
title_fullStr	Increased risk of major depressive disorder in sleep apnea patients in Taiwan
title_full_unstemmed	Increased risk of major depressive disorder in sleep apnea patients in Taiwan
title_sort	increased risk of major depressive disorder in sleep apnea patients in taiwan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6290628cee2c41d9a2844b9c6db6053b
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_version_	1718392083136380928

Increased risk of major depressive disorder in sleep apnea patients in Taiwan

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