The effect of genetic polymorphisms on treatment duration following premolar extraction

Abstract To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the associat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiyon Yu, Yoon Jeong Choi, Sung-Hwan Choi, Han-Sung Jung, Ji Hyun Lee, Jung-Yul Cha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62924efee3e54bcfa9ce8f683a882ec4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62924efee3e54bcfa9ce8f683a882ec4
record_format	dspace
spelling	oai:doaj.org-article:62924efee3e54bcfa9ce8f683a882ec42021-12-02T18:49:32ZThe effect of genetic polymorphisms on treatment duration following premolar extraction10.1038/s41598-021-94979-82045-2322https://doaj.org/article/62924efee3e54bcfa9ce8f683a882ec42021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94979-8https://doaj.org/toc/2045-2322Abstract To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, TT genotype of SPP1 (rs1126616), and GG genotype of SFRP2 was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of SPP1, AA genotype of P2RX7, CT genotype of TNFSF11, and AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.Jiyon YuYoon Jeong ChoiSung-Hwan ChoiHan-Sung JungJi Hyun LeeJung-Yul ChaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiyon Yu Yoon Jeong Choi Sung-Hwan Choi Han-Sung Jung Ji Hyun Lee Jung-Yul Cha The effect of genetic polymorphisms on treatment duration following premolar extraction
description	Abstract To elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, TT genotype of SPP1 (rs1126616), and GG genotype of SFRP2 was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of SPP1, AA genotype of P2RX7, CT genotype of TNFSF11, and AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.
format	article
author	Jiyon Yu Yoon Jeong Choi Sung-Hwan Choi Han-Sung Jung Ji Hyun Lee Jung-Yul Cha
author_facet	Jiyon Yu Yoon Jeong Choi Sung-Hwan Choi Han-Sung Jung Ji Hyun Lee Jung-Yul Cha
author_sort	Jiyon Yu
title	The effect of genetic polymorphisms on treatment duration following premolar extraction
title_short	The effect of genetic polymorphisms on treatment duration following premolar extraction
title_full	The effect of genetic polymorphisms on treatment duration following premolar extraction
title_fullStr	The effect of genetic polymorphisms on treatment duration following premolar extraction
title_full_unstemmed	The effect of genetic polymorphisms on treatment duration following premolar extraction
title_sort	effect of genetic polymorphisms on treatment duration following premolar extraction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62924efee3e54bcfa9ce8f683a882ec4
work_keys_str_mv	AT jiyonyu theeffectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT yoonjeongchoi theeffectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT sunghwanchoi theeffectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT hansungjung theeffectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT jihyunlee theeffectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT jungyulcha theeffectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT jiyonyu effectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT yoonjeongchoi effectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT sunghwanchoi effectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT hansungjung effectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT jihyunlee effectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction AT jungyulcha effectofgeneticpolymorphismsontreatmentdurationfollowingpremolarextraction
_version_	1718377564031942656

The effect of genetic polymorphisms on treatment duration following premolar extraction

Ejemplares similares