Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.

<h4>Background</h4>Although focal epilepsies are increasingly recognized to affect multiple and remote neural systems, the underlying spatiotemporal pattern and the relationships between recurrent spontaneous seizures, global functional connectivity, and structural integrity remain large...

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Autores principales:	Willem M Otte, Rick M Dijkhuizen, Maurits P A van Meer, Wilhelmina S van der Hel, Suzanne A M W Verlinde, Onno van Nieuwenhuizen, Max A Viergever, Cornelis J Stam, Kees P J Braun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6292fe84a717453e8242be5c8d4bce20
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spelling	oai:doaj.org-article:6292fe84a717453e8242be5c8d4bce202021-11-18T07:12:42ZCharacterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.1932-620310.1371/journal.pone.0039078https://doaj.org/article/6292fe84a717453e8242be5c8d4bce202012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22808026/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Although focal epilepsies are increasingly recognized to affect multiple and remote neural systems, the underlying spatiotemporal pattern and the relationships between recurrent spontaneous seizures, global functional connectivity, and structural integrity remain largely unknown.<h4>Methodology/principal findings</h4>Here we utilized serial resting-state functional MRI, graph-theoretical analysis of complex brain networks and diffusion tensor imaging to characterize the evolution of global network topology, functional connectivity and structural changes in the interictal brain in relation to focal epilepsy in a rat model. Epileptic networks exhibited a more regular functional topology than controls, indicated by a significant increase in shortest path length and clustering coefficient. Interhemispheric functional connectivity in epileptic brains decreased, while intrahemispheric functional connectivity increased. Widespread reductions of fractional anisotropy were found in white matter regions not restricted to the vicinity of the epileptic focus, including the corpus callosum.<h4>Conclusions/significance</h4>Our longitudinal study on the pathogenesis of network dynamics in epileptic brains reveals that, despite the locality of the epileptogenic area, epileptic brains differ in their global network topology, connectivity and structural integrity from healthy brains.Willem M OtteRick M DijkhuizenMaurits P A van MeerWilhelmina S van der HelSuzanne A M W VerlindeOnno van NieuwenhuizenMax A ViergeverCornelis J StamKees P J BraunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e39078 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Willem M Otte Rick M Dijkhuizen Maurits P A van Meer Wilhelmina S van der Hel Suzanne A M W Verlinde Onno van Nieuwenhuizen Max A Viergever Cornelis J Stam Kees P J Braun Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.
description	<h4>Background</h4>Although focal epilepsies are increasingly recognized to affect multiple and remote neural systems, the underlying spatiotemporal pattern and the relationships between recurrent spontaneous seizures, global functional connectivity, and structural integrity remain largely unknown.<h4>Methodology/principal findings</h4>Here we utilized serial resting-state functional MRI, graph-theoretical analysis of complex brain networks and diffusion tensor imaging to characterize the evolution of global network topology, functional connectivity and structural changes in the interictal brain in relation to focal epilepsy in a rat model. Epileptic networks exhibited a more regular functional topology than controls, indicated by a significant increase in shortest path length and clustering coefficient. Interhemispheric functional connectivity in epileptic brains decreased, while intrahemispheric functional connectivity increased. Widespread reductions of fractional anisotropy were found in white matter regions not restricted to the vicinity of the epileptic focus, including the corpus callosum.<h4>Conclusions/significance</h4>Our longitudinal study on the pathogenesis of network dynamics in epileptic brains reveals that, despite the locality of the epileptogenic area, epileptic brains differ in their global network topology, connectivity and structural integrity from healthy brains.
format	article
author	Willem M Otte Rick M Dijkhuizen Maurits P A van Meer Wilhelmina S van der Hel Suzanne A M W Verlinde Onno van Nieuwenhuizen Max A Viergever Cornelis J Stam Kees P J Braun
author_facet	Willem M Otte Rick M Dijkhuizen Maurits P A van Meer Wilhelmina S van der Hel Suzanne A M W Verlinde Onno van Nieuwenhuizen Max A Viergever Cornelis J Stam Kees P J Braun
author_sort	Willem M Otte
title	Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.
title_short	Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.
title_full	Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.
title_fullStr	Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.
title_full_unstemmed	Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.
title_sort	characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6292fe84a717453e8242be5c8d4bce20
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Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes.

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