Patient derived organoids to model rare prostate cancer phenotypes

There are few available models to study neuroendocrine prostate cancer. Here they develop and characterize patient derived organoids from metastatic lesions, use these models to show the role of EZH2 in driving neuroendocrine phenotype, and perform high throughput organoid screening to identify ther...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Loredana Puca, Rohan Bareja, Davide Prandi, Reid Shaw, Matteo Benelli, Wouter R. Karthaus, Judy Hess, Michael Sigouros, Adam Donoghue, Myriam Kossai, Dong Gao, Joanna Cyrta, Verena Sailer, Aram Vosoughi, Chantal Pauli, Yelena Churakova, Cynthia Cheung, Lesa Dayal Deonarine, Terra J. McNary, Rachele Rosati, Scott T. Tagawa, David M. Nanus, Juan Miguel Mosquera, Charles L. Sawyers, Yu Chen, Giorgio Inghirami, Rema A. Rao, Carla Grandori, Olivier Elemento, Andrea Sboner, Francesca Demichelis, Mark A. Rubin, Himisha Beltran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6298c3191ca44642a1ee5adc286008a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6298c3191ca44642a1ee5adc286008a4
record_format	dspace
spelling	oai:doaj.org-article:6298c3191ca44642a1ee5adc286008a42021-12-02T15:33:40ZPatient derived organoids to model rare prostate cancer phenotypes10.1038/s41467-018-04495-z2041-1723https://doaj.org/article/6298c3191ca44642a1ee5adc286008a42018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04495-zhttps://doaj.org/toc/2041-1723There are few available models to study neuroendocrine prostate cancer. Here they develop and characterize patient derived organoids from metastatic lesions, use these models to show the role of EZH2 in driving neuroendocrine phenotype, and perform high throughput organoid screening to identify therapeutic drug combinations.Loredana PucaRohan BarejaDavide PrandiReid ShawMatteo BenelliWouter R. KarthausJudy HessMichael SigourosAdam DonoghueMyriam KossaiDong GaoJoanna CyrtaVerena SailerAram VosoughiChantal PauliYelena ChurakovaCynthia CheungLesa Dayal DeonarineTerra J. McNaryRachele RosatiScott T. TagawaDavid M. NanusJuan Miguel MosqueraCharles L. SawyersYu ChenGiorgio InghiramiRema A. RaoCarla GrandoriOlivier ElementoAndrea SbonerFrancesca DemichelisMark A. RubinHimisha BeltranNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Loredana Puca Rohan Bareja Davide Prandi Reid Shaw Matteo Benelli Wouter R. Karthaus Judy Hess Michael Sigouros Adam Donoghue Myriam Kossai Dong Gao Joanna Cyrta Verena Sailer Aram Vosoughi Chantal Pauli Yelena Churakova Cynthia Cheung Lesa Dayal Deonarine Terra J. McNary Rachele Rosati Scott T. Tagawa David M. Nanus Juan Miguel Mosquera Charles L. Sawyers Yu Chen Giorgio Inghirami Rema A. Rao Carla Grandori Olivier Elemento Andrea Sboner Francesca Demichelis Mark A. Rubin Himisha Beltran Patient derived organoids to model rare prostate cancer phenotypes
description	There are few available models to study neuroendocrine prostate cancer. Here they develop and characterize patient derived organoids from metastatic lesions, use these models to show the role of EZH2 in driving neuroendocrine phenotype, and perform high throughput organoid screening to identify therapeutic drug combinations.
format	article
author	Loredana Puca Rohan Bareja Davide Prandi Reid Shaw Matteo Benelli Wouter R. Karthaus Judy Hess Michael Sigouros Adam Donoghue Myriam Kossai Dong Gao Joanna Cyrta Verena Sailer Aram Vosoughi Chantal Pauli Yelena Churakova Cynthia Cheung Lesa Dayal Deonarine Terra J. McNary Rachele Rosati Scott T. Tagawa David M. Nanus Juan Miguel Mosquera Charles L. Sawyers Yu Chen Giorgio Inghirami Rema A. Rao Carla Grandori Olivier Elemento Andrea Sboner Francesca Demichelis Mark A. Rubin Himisha Beltran
author_facet	Loredana Puca Rohan Bareja Davide Prandi Reid Shaw Matteo Benelli Wouter R. Karthaus Judy Hess Michael Sigouros Adam Donoghue Myriam Kossai Dong Gao Joanna Cyrta Verena Sailer Aram Vosoughi Chantal Pauli Yelena Churakova Cynthia Cheung Lesa Dayal Deonarine Terra J. McNary Rachele Rosati Scott T. Tagawa David M. Nanus Juan Miguel Mosquera Charles L. Sawyers Yu Chen Giorgio Inghirami Rema A. Rao Carla Grandori Olivier Elemento Andrea Sboner Francesca Demichelis Mark A. Rubin Himisha Beltran
author_sort	Loredana Puca
title	Patient derived organoids to model rare prostate cancer phenotypes
title_short	Patient derived organoids to model rare prostate cancer phenotypes
title_full	Patient derived organoids to model rare prostate cancer phenotypes
title_fullStr	Patient derived organoids to model rare prostate cancer phenotypes
title_full_unstemmed	Patient derived organoids to model rare prostate cancer phenotypes
title_sort	patient derived organoids to model rare prostate cancer phenotypes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6298c3191ca44642a1ee5adc286008a4
work_keys_str_mv	AT loredanapuca patientderivedorganoidstomodelrareprostatecancerphenotypes AT rohanbareja patientderivedorganoidstomodelrareprostatecancerphenotypes AT davideprandi patientderivedorganoidstomodelrareprostatecancerphenotypes AT reidshaw patientderivedorganoidstomodelrareprostatecancerphenotypes AT matteobenelli patientderivedorganoidstomodelrareprostatecancerphenotypes AT wouterrkarthaus patientderivedorganoidstomodelrareprostatecancerphenotypes AT judyhess patientderivedorganoidstomodelrareprostatecancerphenotypes AT michaelsigouros patientderivedorganoidstomodelrareprostatecancerphenotypes AT adamdonoghue patientderivedorganoidstomodelrareprostatecancerphenotypes AT myriamkossai patientderivedorganoidstomodelrareprostatecancerphenotypes AT donggao patientderivedorganoidstomodelrareprostatecancerphenotypes AT joannacyrta patientderivedorganoidstomodelrareprostatecancerphenotypes AT verenasailer patientderivedorganoidstomodelrareprostatecancerphenotypes AT aramvosoughi patientderivedorganoidstomodelrareprostatecancerphenotypes AT chantalpauli patientderivedorganoidstomodelrareprostatecancerphenotypes AT yelenachurakova patientderivedorganoidstomodelrareprostatecancerphenotypes AT cynthiacheung patientderivedorganoidstomodelrareprostatecancerphenotypes AT lesadayaldeonarine patientderivedorganoidstomodelrareprostatecancerphenotypes AT terrajmcnary patientderivedorganoidstomodelrareprostatecancerphenotypes AT rachelerosati patientderivedorganoidstomodelrareprostatecancerphenotypes AT scottttagawa patientderivedorganoidstomodelrareprostatecancerphenotypes AT davidmnanus patientderivedorganoidstomodelrareprostatecancerphenotypes AT juanmiguelmosquera patientderivedorganoidstomodelrareprostatecancerphenotypes AT charleslsawyers patientderivedorganoidstomodelrareprostatecancerphenotypes AT yuchen patientderivedorganoidstomodelrareprostatecancerphenotypes AT giorgioinghirami patientderivedorganoidstomodelrareprostatecancerphenotypes AT remaarao patientderivedorganoidstomodelrareprostatecancerphenotypes AT carlagrandori patientderivedorganoidstomodelrareprostatecancerphenotypes AT olivierelemento patientderivedorganoidstomodelrareprostatecancerphenotypes AT andreasboner patientderivedorganoidstomodelrareprostatecancerphenotypes AT francescademichelis patientderivedorganoidstomodelrareprostatecancerphenotypes AT markarubin patientderivedorganoidstomodelrareprostatecancerphenotypes AT himishabeltran patientderivedorganoidstomodelrareprostatecancerphenotypes
_version_	1718387027140935680

Patient derived organoids to model rare prostate cancer phenotypes

Ejemplares similares