Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture

Pesticide residues are largely found in daily consumed food because of their extensive use in farming and their long half-life, which prolongs their presence in the environment. Many of these pesticides act as endocrine-disrupting chemicals after pre- or postnatal exposure, significantly affecting,...

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Autores principales:	Anastasia Konstantina Sakali, Alexandra Bargiota, Ioannis G. Fatouros, Athanasios Jamurtas, Djuro Macut, George Mastorakos, Maria Papagianni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nutrition pesticides endocrine disruptors puberty onset sexual maturation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/629bd2c7d30f42cdbfc33b3b62a76d57
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spelling	oai:doaj.org-article:629bd2c7d30f42cdbfc33b3b62a76d572021-11-25T18:37:24ZEffects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture10.3390/nu131141842072-6643https://doaj.org/article/629bd2c7d30f42cdbfc33b3b62a76d572021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4184https://doaj.org/toc/2072-6643Pesticide residues are largely found in daily consumed food because of their extensive use in farming and their long half-life, which prolongs their presence in the environment. Many of these pesticides act as endocrine-disrupting chemicals after pre- or postnatal exposure, significantly affecting, among other things, the time of puberty onset, progression, and completion. In humans, precocious or delayed puberty, and early or delayed sexual maturation, may entail several negative long-term health implications. In this review, we summarize the current evidence on the impact of endocrine-disrupting pesticides upon the timing of the landmarks of female and male puberty in both animals (vaginal opening, first estrus, and balanopreputial separation) and humans (thelarche, menarche, gonadarche). Moreover, we explore the possible mechanisms of action of the reviewed endocrine-disrupting pesticides on the human reproductive system. Access to safe, healthy, and nutritious food is fundamental for the maintenance of health and wellbeing. Eliminating the presence of hazardous chemicals in largely consumed food products may increase their nutritional value and be proven beneficial for overall health. Consequently, understanding the effects of human exposure to hazardous endocrine-disrupting pesticides, and legislating against their circulation, are of major importance for the protection of health in vulnerable populations, such as children and adolescents.Anastasia Konstantina SakaliAlexandra BargiotaIoannis G. FatourosAthanasios JamurtasDjuro MacutGeorge MastorakosMaria PapagianniMDPI AGarticlenutritionpesticidesendocrine disruptorspuberty onsetsexual maturationNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4184, p 4184 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nutrition pesticides endocrine disruptors puberty onset sexual maturation Nutrition. Foods and food supply TX341-641
spellingShingle	nutrition pesticides endocrine disruptors puberty onset sexual maturation Nutrition. Foods and food supply TX341-641 Anastasia Konstantina Sakali Alexandra Bargiota Ioannis G. Fatouros Athanasios Jamurtas Djuro Macut George Mastorakos Maria Papagianni Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture
description	Pesticide residues are largely found in daily consumed food because of their extensive use in farming and their long half-life, which prolongs their presence in the environment. Many of these pesticides act as endocrine-disrupting chemicals after pre- or postnatal exposure, significantly affecting, among other things, the time of puberty onset, progression, and completion. In humans, precocious or delayed puberty, and early or delayed sexual maturation, may entail several negative long-term health implications. In this review, we summarize the current evidence on the impact of endocrine-disrupting pesticides upon the timing of the landmarks of female and male puberty in both animals (vaginal opening, first estrus, and balanopreputial separation) and humans (thelarche, menarche, gonadarche). Moreover, we explore the possible mechanisms of action of the reviewed endocrine-disrupting pesticides on the human reproductive system. Access to safe, healthy, and nutritious food is fundamental for the maintenance of health and wellbeing. Eliminating the presence of hazardous chemicals in largely consumed food products may increase their nutritional value and be proven beneficial for overall health. Consequently, understanding the effects of human exposure to hazardous endocrine-disrupting pesticides, and legislating against their circulation, are of major importance for the protection of health in vulnerable populations, such as children and adolescents.
format	article
author	Anastasia Konstantina Sakali Alexandra Bargiota Ioannis G. Fatouros Athanasios Jamurtas Djuro Macut George Mastorakos Maria Papagianni
author_facet	Anastasia Konstantina Sakali Alexandra Bargiota Ioannis G. Fatouros Athanasios Jamurtas Djuro Macut George Mastorakos Maria Papagianni
author_sort	Anastasia Konstantina Sakali
title	Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture
title_short	Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture
title_full	Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture
title_fullStr	Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture
title_full_unstemmed	Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture
title_sort	effects on puberty of nutrition-mediated endocrine disruptors employed in agriculture
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/629bd2c7d30f42cdbfc33b3b62a76d57
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Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture

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