Leucine regulates autophagy via acetylation of the mTORC1 component raptor

Leucine is a critical amino acid that inhibits autophagy. Here, the authors show that the leucine inhibits autophagy in most cell types, predominantly via its catabolite acetyl CoA, which drives acetylation of raptor, which activates mTORC1, a negative regulator of this catabolic process.

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Autores principales:	Sung Min Son, So Jung Park, Eleanna Stamatakou, Mariella Vicinanza, Fiona M. Menzies, David C. Rubinsztein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/629c1efbd3634ae6b0d6ad330b8f9c16
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spelling	oai:doaj.org-article:629c1efbd3634ae6b0d6ad330b8f9c162021-12-02T16:04:34ZLeucine regulates autophagy via acetylation of the mTORC1 component raptor10.1038/s41467-020-16886-22041-1723https://doaj.org/article/629c1efbd3634ae6b0d6ad330b8f9c162020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16886-2https://doaj.org/toc/2041-1723Leucine is a critical amino acid that inhibits autophagy. Here, the authors show that the leucine inhibits autophagy in most cell types, predominantly via its catabolite acetyl CoA, which drives acetylation of raptor, which activates mTORC1, a negative regulator of this catabolic process.Sung Min SonSo Jung ParkEleanna StamatakouMariella VicinanzaFiona M. MenziesDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sung Min Son So Jung Park Eleanna Stamatakou Mariella Vicinanza Fiona M. Menzies David C. Rubinsztein Leucine regulates autophagy via acetylation of the mTORC1 component raptor
description	Leucine is a critical amino acid that inhibits autophagy. Here, the authors show that the leucine inhibits autophagy in most cell types, predominantly via its catabolite acetyl CoA, which drives acetylation of raptor, which activates mTORC1, a negative regulator of this catabolic process.
format	article
author	Sung Min Son So Jung Park Eleanna Stamatakou Mariella Vicinanza Fiona M. Menzies David C. Rubinsztein
author_facet	Sung Min Son So Jung Park Eleanna Stamatakou Mariella Vicinanza Fiona M. Menzies David C. Rubinsztein
author_sort	Sung Min Son
title	Leucine regulates autophagy via acetylation of the mTORC1 component raptor
title_short	Leucine regulates autophagy via acetylation of the mTORC1 component raptor
title_full	Leucine regulates autophagy via acetylation of the mTORC1 component raptor
title_fullStr	Leucine regulates autophagy via acetylation of the mTORC1 component raptor
title_full_unstemmed	Leucine regulates autophagy via acetylation of the mTORC1 component raptor
title_sort	leucine regulates autophagy via acetylation of the mtorc1 component raptor
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/629c1efbd3634ae6b0d6ad330b8f9c16
work_keys_str_mv	AT sungminson leucineregulatesautophagyviaacetylationofthemtorc1componentraptor AT sojungpark leucineregulatesautophagyviaacetylationofthemtorc1componentraptor AT eleannastamatakou leucineregulatesautophagyviaacetylationofthemtorc1componentraptor AT mariellavicinanza leucineregulatesautophagyviaacetylationofthemtorc1componentraptor AT fionammenzies leucineregulatesautophagyviaacetylationofthemtorc1componentraptor AT davidcrubinsztein leucineregulatesautophagyviaacetylationofthemtorc1componentraptor
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Leucine regulates autophagy via acetylation of the mTORC1 component raptor

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