Engineering of a bona fide light-operated calcium channel

Existing optogenetic methods to induce calcium mobilisation lack selectivity and specificity. Here, the authors design and engineer a single-component light-operated calcium channel to provide optical control over calcium signals and calcium-dependent physiological responses: LOCa.

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Autores principales:	Lian He, Liuqing Wang, Hongxiang Zeng, Peng Tan, Guolin Ma, Sisi Zheng, Yaxin Li, Lin Sun, Fei Dou, Stefan Siwko, Yun Huang, Youjun Wang, Yubin Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62a2bcdaa2fd4fe79a851bd0dc9573de
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spelling	oai:doaj.org-article:62a2bcdaa2fd4fe79a851bd0dc9573de2021-12-02T14:12:04ZEngineering of a bona fide light-operated calcium channel10.1038/s41467-020-20425-42041-1723https://doaj.org/article/62a2bcdaa2fd4fe79a851bd0dc9573de2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20425-4https://doaj.org/toc/2041-1723Existing optogenetic methods to induce calcium mobilisation lack selectivity and specificity. Here, the authors design and engineer a single-component light-operated calcium channel to provide optical control over calcium signals and calcium-dependent physiological responses: LOCa.Lian HeLiuqing WangHongxiang ZengPeng TanGuolin MaSisi ZhengYaxin LiLin SunFei DouStefan SiwkoYun HuangYoujun WangYubin ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lian He Liuqing Wang Hongxiang Zeng Peng Tan Guolin Ma Sisi Zheng Yaxin Li Lin Sun Fei Dou Stefan Siwko Yun Huang Youjun Wang Yubin Zhou Engineering of a bona fide light-operated calcium channel
description	Existing optogenetic methods to induce calcium mobilisation lack selectivity and specificity. Here, the authors design and engineer a single-component light-operated calcium channel to provide optical control over calcium signals and calcium-dependent physiological responses: LOCa.
format	article
author	Lian He Liuqing Wang Hongxiang Zeng Peng Tan Guolin Ma Sisi Zheng Yaxin Li Lin Sun Fei Dou Stefan Siwko Yun Huang Youjun Wang Yubin Zhou
author_facet	Lian He Liuqing Wang Hongxiang Zeng Peng Tan Guolin Ma Sisi Zheng Yaxin Li Lin Sun Fei Dou Stefan Siwko Yun Huang Youjun Wang Yubin Zhou
author_sort	Lian He
title	Engineering of a bona fide light-operated calcium channel
title_short	Engineering of a bona fide light-operated calcium channel
title_full	Engineering of a bona fide light-operated calcium channel
title_fullStr	Engineering of a bona fide light-operated calcium channel
title_full_unstemmed	Engineering of a bona fide light-operated calcium channel
title_sort	engineering of a bona fide light-operated calcium channel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62a2bcdaa2fd4fe79a851bd0dc9573de
work_keys_str_mv	AT lianhe engineeringofabonafidelightoperatedcalciumchannel AT liuqingwang engineeringofabonafidelightoperatedcalciumchannel AT hongxiangzeng engineeringofabonafidelightoperatedcalciumchannel AT pengtan engineeringofabonafidelightoperatedcalciumchannel AT guolinma engineeringofabonafidelightoperatedcalciumchannel AT sisizheng engineeringofabonafidelightoperatedcalciumchannel AT yaxinli engineeringofabonafidelightoperatedcalciumchannel AT linsun engineeringofabonafidelightoperatedcalciumchannel AT feidou engineeringofabonafidelightoperatedcalciumchannel AT stefansiwko engineeringofabonafidelightoperatedcalciumchannel AT yunhuang engineeringofabonafidelightoperatedcalciumchannel AT youjunwang engineeringofabonafidelightoperatedcalciumchannel AT yubinzhou engineeringofabonafidelightoperatedcalciumchannel
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Engineering of a bona fide light-operated calcium channel

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