Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

Jun Wang1, Yue Chen1, Baoan Chen1, Jiahua Ding1, Guohua Xia1, Chong Gao1, Jian Cheng1, Nan Jin1, Ying Zhou1, Xiaomao Li1, Meng Tang2, Xue Mei Wang21Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People&rsquo;s Republic of China; 1Departmen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jun Wang, Yue Chen, Baoan Chen, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/62a3149bf5b64e85a2d32df9b3dd4c1a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62a3149bf5b64e85a2d32df9b3dd4c1a
record_format	dspace
spelling	oai:doaj.org-article:62a3149bf5b64e85a2d32df9b3dd4c1a2021-12-02T08:08:32ZPharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice1176-91141178-2013https://doaj.org/article/62a3149bf5b64e85a2d32df9b3dd4c1a2010-10-01T00:00:00Zhttp://www.dovepress.com/pharmacokinetic-parameters-and-tissue-distribution-of-magnetic-fe3o4-n-a5495https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jun Wang1, Yue Chen1, Baoan Chen1, Jiahua Ding1, Guohua Xia1, Chong Gao1, Jian Cheng1, Nan Jin1, Ying Zhou1, Xiaomao Li1, Meng Tang2, Xue Mei Wang21Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People&rsquo;s Republic of China; 1Department of Physics, University of Saarland, D-266041 Saarbruechen, Germany; 2National Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, People&rsquo;s Republic of ChinaBackground: This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe3O4 MNPs) in imprinting control region (ICR) mice.Methods: The Fe3O4 MNPs were synthesized by chemical coprecipitation, and their morphology and appearance were observed by transmission electron microscopy. ICR mice were divided into a control group and a Fe3O4 MNP-treated group. Probable target organs in ICR mice were observed, and the pharmacokinetic parameters and biodistribution of Fe3O4 MNPs in tissues were identified using atomic absorption spectrophotometry.Results: Fe3O4 MNPs were spherical with a well distributed particle diameter, and were distributed widely in various target organs and tissues including the heart, liver, spleen, lungs, kidneys, brain, stomach, small intestine, and bone marrow. The majority of Fe3O4 MNPs were distributed to the liver and the spleen. Fe3O4 MNP levels in brain tissue were higher in the Fe3O4 MNP-treated group than in the control group, indicating that Fe3O4 MNPs can penetrate the blood&ndash;brain barrier.Conclusion: These results suggest that the distribution of Fe3O4 MNPs was mostly in the liver and spleen, so the curative effect of these compounds could be more pronounced for liver tumors. Furthermore, Fe3O4 MNPs might be used as drug carriers to overcome physiologic barriers.Keywords: magnetic nanoparticles, Fe3O4, tissue distribution, mice Jun WangYue ChenBaoan Chenet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 861-866 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jun Wang Yue Chen Baoan Chen et al Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice
description	Jun Wang1, Yue Chen1, Baoan Chen1, Jiahua Ding1, Guohua Xia1, Chong Gao1, Jian Cheng1, Nan Jin1, Ying Zhou1, Xiaomao Li1, Meng Tang2, Xue Mei Wang21Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People&rsquo;s Republic of China; 1Department of Physics, University of Saarland, D-266041 Saarbruechen, Germany; 2National Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, People&rsquo;s Republic of ChinaBackground: This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe3O4 MNPs) in imprinting control region (ICR) mice.Methods: The Fe3O4 MNPs were synthesized by chemical coprecipitation, and their morphology and appearance were observed by transmission electron microscopy. ICR mice were divided into a control group and a Fe3O4 MNP-treated group. Probable target organs in ICR mice were observed, and the pharmacokinetic parameters and biodistribution of Fe3O4 MNPs in tissues were identified using atomic absorption spectrophotometry.Results: Fe3O4 MNPs were spherical with a well distributed particle diameter, and were distributed widely in various target organs and tissues including the heart, liver, spleen, lungs, kidneys, brain, stomach, small intestine, and bone marrow. The majority of Fe3O4 MNPs were distributed to the liver and the spleen. Fe3O4 MNP levels in brain tissue were higher in the Fe3O4 MNP-treated group than in the control group, indicating that Fe3O4 MNPs can penetrate the blood&ndash;brain barrier.Conclusion: These results suggest that the distribution of Fe3O4 MNPs was mostly in the liver and spleen, so the curative effect of these compounds could be more pronounced for liver tumors. Furthermore, Fe3O4 MNPs might be used as drug carriers to overcome physiologic barriers.Keywords: magnetic nanoparticles, Fe3O4, tissue distribution, mice
format	article
author	Jun Wang Yue Chen Baoan Chen et al
author_facet	Jun Wang Yue Chen Baoan Chen et al
author_sort	Jun Wang
title	Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice
title_short	Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice
title_full	Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice
title_fullStr	Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice
title_full_unstemmed	Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice
title_sort	pharmacokinetic parameters and tissue distribution of magnetic fe3o4 nanoparticles in mice
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/62a3149bf5b64e85a2d32df9b3dd4c1a
work_keys_str_mv	AT junwang pharmacokineticparametersandtissuedistributionofmagneticfe3o4nanoparticlesinmice AT yuechen pharmacokineticparametersandtissuedistributionofmagneticfe3o4nanoparticlesinmice AT baoanchen pharmacokineticparametersandtissuedistributionofmagneticfe3o4nanoparticlesinmice AT etal pharmacokineticparametersandtissuedistributionofmagneticfe3o4nanoparticlesinmice
_version_	1718398603104354304

Pharmacokinetic parameters and tissue distribution of magnetic Fe3O4 nanoparticles in mice

Ejemplares similares