A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin

Abstract The question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent orientation of planar cell division in the mammalian embryonic skin. We...

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Autores principales:	Fazal Oozeer, Laura L. Yates, Charlotte Dean, Caroline J. Formstone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62a4d175324644f88e14020e4b8b7bb1
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spelling	oai:doaj.org-article:62a4d175324644f88e14020e4b8b7bb12021-12-02T12:32:01ZA role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin10.1038/s41598-017-01971-22045-2322https://doaj.org/article/62a4d175324644f88e14020e4b8b7bb12017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01971-2https://doaj.org/toc/2045-2322Abstract The question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent orientation of planar cell division in the mammalian embryonic skin. We propose a model where the core planar polarity proteins Celsr1 and Frizzled-6 (Fz6) communicate the long axis orientation of interphase basal cells to neighbouring basal mitoses so that they align their horizontal division plane along the same axis. The underlying mechanism requires a direct, cell surface, planar polarised cue, which we posit depends upon variant post-translational forms of Celsr1 protein coupled to Fz6. Our hypothesis has parallels with contact-mediated division orientation in early C. elegans embryos suggesting functional conservation between the adhesion-GPCRs Celsr1 and Latrophilin-1. We propose that linking planar cell division plane with interphase neighbour long axis geometry reinforces axial bias in skin spreading around the mouse embryo body.Fazal OozeerLaura L. YatesCharlotte DeanCaroline J. FormstoneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fazal Oozeer Laura L. Yates Charlotte Dean Caroline J. Formstone A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
description	Abstract The question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent orientation of planar cell division in the mammalian embryonic skin. We propose a model where the core planar polarity proteins Celsr1 and Frizzled-6 (Fz6) communicate the long axis orientation of interphase basal cells to neighbouring basal mitoses so that they align their horizontal division plane along the same axis. The underlying mechanism requires a direct, cell surface, planar polarised cue, which we posit depends upon variant post-translational forms of Celsr1 protein coupled to Fz6. Our hypothesis has parallels with contact-mediated division orientation in early C. elegans embryos suggesting functional conservation between the adhesion-GPCRs Celsr1 and Latrophilin-1. We propose that linking planar cell division plane with interphase neighbour long axis geometry reinforces axial bias in skin spreading around the mouse embryo body.
format	article
author	Fazal Oozeer Laura L. Yates Charlotte Dean Caroline J. Formstone
author_facet	Fazal Oozeer Laura L. Yates Charlotte Dean Caroline J. Formstone
author_sort	Fazal Oozeer
title	A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
title_short	A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
title_full	A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
title_fullStr	A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
title_full_unstemmed	A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
title_sort	role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/62a4d175324644f88e14020e4b8b7bb1
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A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin

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