Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span

Abstract Cerebral artery morphological alterations have been associated with several cerebrovascular and neurological diseases, whereas these structures are known to be highly variable among healthy individuals. To date, the knowledge about the influence of cardiovascular risk factors on the morphol...

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Autores principales:	Pauline Mouches, Sönke Langner, Martin Domin, Michael D. Hill, Nils D. Forkert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62a86430850e46aba194520df526a51a
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spelling	oai:doaj.org-article:62a86430850e46aba194520df526a51a2021-12-02T17:38:26ZInfluence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span10.1038/s41598-021-91669-32045-2322https://doaj.org/article/62a86430850e46aba194520df526a51a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91669-3https://doaj.org/toc/2045-2322Abstract Cerebral artery morphological alterations have been associated with several cerebrovascular and neurological diseases, whereas these structures are known to be highly variable among healthy individuals. To date, the knowledge about the influence of cardiovascular risk factors on the morphology of cerebral arteries is rather limited. The aim of this work was to investigate the impact of cardiovascular risk factors on the regional cerebroarterial radius and density. Time-of-Flight magnetic resonance angiography from 1722 healthy adults (21–82 years) were used to extract region-specific measurements describing the main cerebral artery morphology. Multivariate statistical analysis was conducted to quantify the impact of cardiovascular risk factors, including clinical and life behavioural factors, on each region-specific artery measurement. Increased age, blood pressure, and markers of obesity were significantly associated with decreased artery radius and density in most regions, with aging having the greatest impact. Additionally, females showed significantly higher artery density while males showed higher artery radius. Smoking and alcohol consumption did not show any significant association with the artery morphology. The results of this study improve the understanding of the impact of aging, clinical factors, and life behavioural factors on cerebrovascular morphology and can help to identify potential risk factors for cerebrovascular and neurological diseases.Pauline MouchesSönke LangnerMartin DominMichael D. HillNils D. ForkertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pauline Mouches Sönke Langner Martin Domin Michael D. Hill Nils D. Forkert Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span
description	Abstract Cerebral artery morphological alterations have been associated with several cerebrovascular and neurological diseases, whereas these structures are known to be highly variable among healthy individuals. To date, the knowledge about the influence of cardiovascular risk factors on the morphology of cerebral arteries is rather limited. The aim of this work was to investigate the impact of cardiovascular risk factors on the regional cerebroarterial radius and density. Time-of-Flight magnetic resonance angiography from 1722 healthy adults (21–82 years) were used to extract region-specific measurements describing the main cerebral artery morphology. Multivariate statistical analysis was conducted to quantify the impact of cardiovascular risk factors, including clinical and life behavioural factors, on each region-specific artery measurement. Increased age, blood pressure, and markers of obesity were significantly associated with decreased artery radius and density in most regions, with aging having the greatest impact. Additionally, females showed significantly higher artery density while males showed higher artery radius. Smoking and alcohol consumption did not show any significant association with the artery morphology. The results of this study improve the understanding of the impact of aging, clinical factors, and life behavioural factors on cerebrovascular morphology and can help to identify potential risk factors for cerebrovascular and neurological diseases.
format	article
author	Pauline Mouches Sönke Langner Martin Domin Michael D. Hill Nils D. Forkert
author_facet	Pauline Mouches Sönke Langner Martin Domin Michael D. Hill Nils D. Forkert
author_sort	Pauline Mouches
title	Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span
title_short	Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span
title_full	Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span
title_fullStr	Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span
title_full_unstemmed	Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span
title_sort	influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62a86430850e46aba194520df526a51a
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Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span

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