Pattern of lactoferrin anti-influenza virus inhibitory activity

Active antigenic drift allows the influenza virus to partially or completely avoid recognition by the immune system. For treatment, inhibitors of the proton-selective ion channel M2 and inhibitors of neuraminidase are used, which have undesirable side effects and provoke the emergence of treatment-r...

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Autor principal:	V. N. Zorina
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	lactoferrin peptide viruses influenza therapy adjuvant Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/62aa5821fd9248e48b13e08d1792c968
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spelling	oai:doaj.org-article:62aa5821fd9248e48b13e08d1792c9682021-11-22T07:09:53ZPattern of lactoferrin anti-influenza virus inhibitory activity2220-76192313-739810.15789/2220-7619-POL-1156https://doaj.org/article/62aa5821fd9248e48b13e08d1792c9682020-04-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1156https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Active antigenic drift allows the influenza virus to partially or completely avoid recognition by the immune system. For treatment, inhibitors of the proton-selective ion channel M2 and inhibitors of neuraminidase are used, which have undesirable side effects and provoke the emergence of treatment-resistant strains of the virus. This justifies the need to search for new therapeutic agents. Lactoferrin (LF) is a glycoprotein with a molecular mass of 75—80 kDa, capable for binding metal ions. The highest concentrations of LF are detected in colostrum and milk, a significant amount is deposited in neutrophil granules. The structure of the LF domains of human milk, cow, goat, pig, horse, camel, buffalo is homologous. LF interacts with both specific receptors and endocytosis receptors (LRP), Toll-like, signal receptors on the surface of various cell types. Lactoferrin of humans and animals has a high antiviral activity. This glycoprotein modulates the immune system, including the humoral and cellular immune responses, and regulates redox reactions. However, literature data on the role of this protein in the prevention and treatment of influenza are few. LF inhibitory activity against influenza A and B viruses has been described, including H1N1, H5N1, H7N1, H3N2 strains. It has been established that LF binds virus hemagglutinin, preventing interaction with the cell, blocks programmed cell death through interaction with caspase 3 for preventing the spread of the virus at the later stages of the infection, and blocks virus assembly. Peptides synthesized on the basis of LF C-domain structure demonstrate high inhibitory activity against virus. The use of LF as an adjuvant for vaccines is more effective than of aluminum oxide. Further study of LF effects on influenza virus and on the immune response during infection is necessary to develop new methods of prevention and treatment.V. N. ZorinaSankt-Peterburg : NIIÈM imeni PasteraarticlelactoferrinpeptidevirusesinfluenzatherapyadjuvantInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 1, Pp 49-54 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	lactoferrin peptide viruses influenza therapy adjuvant Infectious and parasitic diseases RC109-216
spellingShingle	lactoferrin peptide viruses influenza therapy adjuvant Infectious and parasitic diseases RC109-216 V. N. Zorina Pattern of lactoferrin anti-influenza virus inhibitory activity
description	Active antigenic drift allows the influenza virus to partially or completely avoid recognition by the immune system. For treatment, inhibitors of the proton-selective ion channel M2 and inhibitors of neuraminidase are used, which have undesirable side effects and provoke the emergence of treatment-resistant strains of the virus. This justifies the need to search for new therapeutic agents. Lactoferrin (LF) is a glycoprotein with a molecular mass of 75—80 kDa, capable for binding metal ions. The highest concentrations of LF are detected in colostrum and milk, a significant amount is deposited in neutrophil granules. The structure of the LF domains of human milk, cow, goat, pig, horse, camel, buffalo is homologous. LF interacts with both specific receptors and endocytosis receptors (LRP), Toll-like, signal receptors on the surface of various cell types. Lactoferrin of humans and animals has a high antiviral activity. This glycoprotein modulates the immune system, including the humoral and cellular immune responses, and regulates redox reactions. However, literature data on the role of this protein in the prevention and treatment of influenza are few. LF inhibitory activity against influenza A and B viruses has been described, including H1N1, H5N1, H7N1, H3N2 strains. It has been established that LF binds virus hemagglutinin, preventing interaction with the cell, blocks programmed cell death through interaction with caspase 3 for preventing the spread of the virus at the later stages of the infection, and blocks virus assembly. Peptides synthesized on the basis of LF C-domain structure demonstrate high inhibitory activity against virus. The use of LF as an adjuvant for vaccines is more effective than of aluminum oxide. Further study of LF effects on influenza virus and on the immune response during infection is necessary to develop new methods of prevention and treatment.
format	article
author	V. N. Zorina
author_facet	V. N. Zorina
author_sort	V. N. Zorina
title	Pattern of lactoferrin anti-influenza virus inhibitory activity
title_short	Pattern of lactoferrin anti-influenza virus inhibitory activity
title_full	Pattern of lactoferrin anti-influenza virus inhibitory activity
title_fullStr	Pattern of lactoferrin anti-influenza virus inhibitory activity
title_full_unstemmed	Pattern of lactoferrin anti-influenza virus inhibitory activity
title_sort	pattern of lactoferrin anti-influenza virus inhibitory activity
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/62aa5821fd9248e48b13e08d1792c968
work_keys_str_mv	AT vnzorina patternoflactoferrinantiinfluenzavirusinhibitoryactivity
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Pattern of lactoferrin anti-influenza virus inhibitory activity

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