TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autopha...

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Autores principales:	Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nüchel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Györfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Jörg H. W. Distler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62b5d5ace81c405bb445c8cf7e9725a7
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spelling	oai:doaj.org-article:62b5d5ace81c405bb445c8cf7e9725a72021-12-02T16:43:42ZTGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy10.1038/s41467-021-24601-y2041-1723https://doaj.org/article/62b5d5ace81c405bb445c8cf7e9725a72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24601-yhttps://doaj.org/toc/2041-1723Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autophagy reduces fibroblast activation and ameliorates fibrotic tissue remodeling.Ariella ZehenderYi-Nan LiNeng-Yu LinAdrian StefanicaJulian NüchelChih-Wei ChenHsiao-Han HsuHonglin ZhuXiao DingJingang HuangLichong ShenAndrea-Hermina GyörfiAlina SoareSimon RauberChristina BergmannAndreas RammingMarkus PlomannBeate EckesGeorg SchettJörg H. W. DistlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ariella Zehender Yi-Nan Li Neng-Yu Lin Adrian Stefanica Julian Nüchel Chih-Wei Chen Hsiao-Han Hsu Honglin Zhu Xiao Ding Jingang Huang Lichong Shen Andrea-Hermina Györfi Alina Soare Simon Rauber Christina Bergmann Andreas Ramming Markus Plomann Beate Eckes Georg Schett Jörg H. W. Distler TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
description	Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autophagy reduces fibroblast activation and ameliorates fibrotic tissue remodeling.
format	article
author	Ariella Zehender Yi-Nan Li Neng-Yu Lin Adrian Stefanica Julian Nüchel Chih-Wei Chen Hsiao-Han Hsu Honglin Zhu Xiao Ding Jingang Huang Lichong Shen Andrea-Hermina Györfi Alina Soare Simon Rauber Christina Bergmann Andreas Ramming Markus Plomann Beate Eckes Georg Schett Jörg H. W. Distler
author_facet	Ariella Zehender Yi-Nan Li Neng-Yu Lin Adrian Stefanica Julian Nüchel Chih-Wei Chen Hsiao-Han Hsu Honglin Zhu Xiao Ding Jingang Huang Lichong Shen Andrea-Hermina Györfi Alina Soare Simon Rauber Christina Bergmann Andreas Ramming Markus Plomann Beate Eckes Georg Schett Jörg H. W. Distler
author_sort	Ariella Zehender
title	TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
title_short	TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
title_full	TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
title_fullStr	TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
title_full_unstemmed	TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy
title_sort	tgfβ promotes fibrosis by myst1-dependent epigenetic regulation of autophagy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62b5d5ace81c405bb445c8cf7e9725a7
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TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

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