The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.

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Autores principales: J. Allen Bennett, Michael A. Mastrangelo, Sara K. Ture, Charles O. Smith, Shannon G. Loelius, Rachel A. Berg, Xu Shi, Ryan M. Burke, Sherry L. Spinelli, Scott J. Cameron, Thomas E. Carey, Paul S. Brookes, Robert E. Gerszten, Maria Sabater-Lleal, Paul S. de Vries, Jennifer E. Huffman, Nicholas L. Smith, Craig N. Morrell, Charles J. Lowenstein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/62b9f79769b2412ba271abefe8be6aa0
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Sumario:Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.

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