The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.

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Autores principales:	J. Allen Bennett, Michael A. Mastrangelo, Sara K. Ture, Charles O. Smith, Shannon G. Loelius, Rachel A. Berg, Xu Shi, Ryan M. Burke, Sherry L. Spinelli, Scott J. Cameron, Thomas E. Carey, Paul S. Brookes, Robert E. Gerszten, Maria Sabater-Lleal, Paul S. de Vries, Jennifer E. Huffman, Nicholas L. Smith, Craig N. Morrell, Charles J. Lowenstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62b9f79769b2412ba271abefe8be6aa0
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spelling	oai:doaj.org-article:62b9f79769b2412ba271abefe8be6aa02021-12-02T16:08:14ZThe choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function10.1038/s41467-020-17254-w2041-1723https://doaj.org/article/62b9f79769b2412ba271abefe8be6aa02020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17254-whttps://doaj.org/toc/2041-1723Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.J. Allen BennettMichael A. MastrangeloSara K. TureCharles O. SmithShannon G. LoeliusRachel A. BergXu ShiRyan M. BurkeSherry L. SpinelliScott J. CameronThomas E. CareyPaul S. BrookesRobert E. GersztenMaria Sabater-LlealPaul S. de VriesJennifer E. HuffmanNicholas L. SmithCraig N. MorrellCharles J. LowensteinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. Allen Bennett Michael A. Mastrangelo Sara K. Ture Charles O. Smith Shannon G. Loelius Rachel A. Berg Xu Shi Ryan M. Burke Sherry L. Spinelli Scott J. Cameron Thomas E. Carey Paul S. Brookes Robert E. Gerszten Maria Sabater-Lleal Paul S. de Vries Jennifer E. Huffman Nicholas L. Smith Craig N. Morrell Charles J. Lowenstein The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
description	Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.
format	article
author	J. Allen Bennett Michael A. Mastrangelo Sara K. Ture Charles O. Smith Shannon G. Loelius Rachel A. Berg Xu Shi Ryan M. Burke Sherry L. Spinelli Scott J. Cameron Thomas E. Carey Paul S. Brookes Robert E. Gerszten Maria Sabater-Lleal Paul S. de Vries Jennifer E. Huffman Nicholas L. Smith Craig N. Morrell Charles J. Lowenstein
author_facet	J. Allen Bennett Michael A. Mastrangelo Sara K. Ture Charles O. Smith Shannon G. Loelius Rachel A. Berg Xu Shi Ryan M. Burke Sherry L. Spinelli Scott J. Cameron Thomas E. Carey Paul S. Brookes Robert E. Gerszten Maria Sabater-Lleal Paul S. de Vries Jennifer E. Huffman Nicholas L. Smith Craig N. Morrell Charles J. Lowenstein
author_sort	J. Allen Bennett
title	The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
title_short	The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
title_full	The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
title_fullStr	The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
title_full_unstemmed	The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
title_sort	choline transporter slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/62b9f79769b2412ba271abefe8be6aa0
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The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

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