A first‐in‐human study of KMRC011, a potential treatment for acute radiation syndrome, to explore tolerability, pharmacokinetics, and pharmacodynamics

Código QR

A first‐in‐human study of KMRC011, a potential treatment for acute radiation syndrome, to explore tolerability, pharmacokinetics, and pharmacodynamics

Abstract KMRC011 is a novel Toll‐like receptor 5 agonist under development as a treatment for acute radiation syndrome (ARS). The aim of this first‐in‐human study was to investigate the tolerability, pharmacokinetics, and pharmacodynamics of a single intramuscular dose of KMRC011 in healthy subjects...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eunsol Yang, Hyejung Choi, Jin‐Sol Park, Young‐Woock Noh, Chi‐Min Choi, Woo‐Jong Lee, Jae‐Wook Ko, Jungryul Kim
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Therapeutics. Pharmacology RM1-950 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/62bbe7029529432185a4241bc6972dba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism
por: Jinhai Wang, et al.
Publicado: (2021)

The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
por: Andrzej Czyrski, et al.
Publicado: (2021)

Co-Administration of Vonoprazan, Not Tegoprazan, Affects the Pharmacokinetics of Atorvastatin in Healthy Male Subjects
por: Sejung Hwang, et al.
Publicado: (2021)

Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin
por: Jarosław Ruczyński, et al.
Publicado: (2019)

Pharmacodynamics and Pharmacokinetics of oral factor Xa inhibitors
por: Persson PB
Publicado: (2015)

Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem
por: Seonghae Yoon, et al.
Publicado: (2021)

Insulin glargine: pharmacokinetic and pharmacodynamic basis of clinical effect
por: Vadim Valer'evich Klimontov, et al.
Publicado: (2014)

Pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections
por: Matsumoto K, et al.
Publicado: (2016)

Concept and utility of population pharmacokinetic and pharmacokinetic/pharmacodynamic models in drug development and clinical practice
por: Roganović Maša, et al.
Publicado: (2021)

A randomized direct comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban
por: Frost C, et al.
Publicado: (2014)

Pharmacokinetic and pharmacodynamic modeling of cyadox against Clostridium perfringens in swine
por: Lei Yan, et al.
Publicado: (2017)

Pharmacodynamic and pharmacokinetic assessment of pulmonary rehabilitation mixture for the treatment of pulmonary fibrosis
por: Juanjuan Zhao, et al.
Publicado: (2017)

A randomized direct comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban [Corrigendum]
por: Frost C, et al.
Publicado: (2018)

Atazanavir–bilirubin interaction: a pharmacokinetic–pharmacodynamic model
por: Lozano R, et al.
Publicado: (2013)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study
por: Gordon D, et al.
Publicado: (2021)

Atazanavir–bilirubin interaction: a pharmacokinetic–pharmacodynamic model [Corrigendum]
por: Lozano R, et al.
Publicado: (2013)

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma
por: Elizabeth C. Randall, et al.
Publicado: (2018)

Evaluation of the single-dose pharmacokinetics and pharmacodynamics of apixaban in healthy Japanese and Caucasian subjects
por: Frost C, et al.
Publicado: (2018)

Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers
por: Nagelschmitz J, et al.
Publicado: (2014)

Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects
por: Cui Y, et al.
Publicado: (2013)

A Phase 1, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Safety, Tolerability, And Pharmacokinetic/Pharmacodynamic Study Of Evolocumab In Healthy Chinese Subjects
por: Liu C, et al.
Publicado: (2019)

A Population Pharmacokinetic and Pharmacodynamic Analysis of Peginesatide in Patients with Chronic Kidney Disease on Dialysis.
por: Himanshu Naik, et al.
Publicado: (2013)

Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects [Corrigendum]
por: Cui Y, et al.
Publicado: (2014)

Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects
por: Rambiritch V, et al.
Publicado: (2016)

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (<i>Salmo trutta</i>)
por: Kamil Uney, et al.
Publicado: (2021)

Pharmacokinetics and pharmacodynamics integration of danofloxacin against Eschrichia coli in piglet ileum ultrafiltration probe model
por: Yuqi Yang, et al.
Publicado: (2021)

Fast-acting insulin aspart: a review of its pharmacokinetic and pharmacodynamic properties and the clinical consequences
por: Hanne Haahr, et al.
Publicado: (2020)

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague&ndash;Dawley rats
por: Vachon P, et al.
Publicado: (2012)

In Vitro Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Amphotericin B against <i>Candida auris</i>
por: Unai Caballero, et al.
Publicado: (2021)

Similar pharmacokinetics and pharmacodynamics of a new biosimilar and reference insulin aspart in healthy Chinese males
por: Hui Liu, et al.
Publicado: (2021)

Lipid-Based Gliclazide Nanoparticles for Treatment of Diabetes: Formulation, Pharmacokinetics, Pharmacodynamics and Subacute Toxicity Study
por: Nazief AM, et al.
Publicado: (2020)

Assessment of Micafungin Dosage Regimens in Patients with Cancer Using Pharmacokinetic/Pharmacodynamic Modeling and Monte Carlo Simulation
por: Saeed Alqahtani, et al.
Publicado: (2021)

Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy
por: Amaya L. Bustinduy, et al.
Publicado: (2016)

Improving pharmacokinetic-pharmacodynamic modeling to investigate anti-infective chemotherapy with application to the current generation of antimalarial drugs.
por: Katherine Kay, et al.
Publicado: (2013)

ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
por: Pavan Vaddady, et al.
Publicado: (2021)

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration
por: Ghaith Aljayyoussi, et al.
Publicado: (2017)

Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305) in patients with advanced solid tumors
por: Wu H, et al.
Publicado: (2015)

Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection
por: Joo-Yun Byun, et al.
Publicado: (2021)

Author Correction: Similar pharmacokinetics and pharmacodynamics of a new biosimilar and reference insulin aspart in healthy Chinese males
por: Hui Liu, et al.
Publicado: (2021)

Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305) in patients with advanced solid tumors [Corrigendum]
por: Wu H, et al.
Publicado: (2019)