Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity

Heyde and Nørholm investigate the role of RNAse E in the toxicity mediated by overexpression of heterologous proteins in derivatives of the BL21(DE3) strain of E. coli. The authors report an unexpected connection between global RNA metabolism and the efficiency of heterologous protein production in...

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Autores principales:	Sophia A. H. Heyde, Morten H. H. Nørholm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/62bfa52235dd4d8f872de90d6665d3a4
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spelling	oai:doaj.org-article:62bfa52235dd4d8f872de90d6665d3a42021-12-02T18:50:46ZTailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity10.1038/s42003-021-02493-42399-3642https://doaj.org/article/62bfa52235dd4d8f872de90d6665d3a42021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02493-4https://doaj.org/toc/2399-3642Heyde and Nørholm investigate the role of RNAse E in the toxicity mediated by overexpression of heterologous proteins in derivatives of the BL21(DE3) strain of E. coli. The authors report an unexpected connection between global RNA metabolism and the efficiency of heterologous protein production in E. coli.Sophia A. H. HeydeMorten H. H. NørholmNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sophia A. H. Heyde Morten H. H. Nørholm Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity
description	Heyde and Nørholm investigate the role of RNAse E in the toxicity mediated by overexpression of heterologous proteins in derivatives of the BL21(DE3) strain of E. coli. The authors report an unexpected connection between global RNA metabolism and the efficiency of heterologous protein production in E. coli.
format	article
author	Sophia A. H. Heyde Morten H. H. Nørholm
author_facet	Sophia A. H. Heyde Morten H. H. Nørholm
author_sort	Sophia A. H. Heyde
title	Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity
title_short	Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity
title_full	Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity
title_fullStr	Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity
title_full_unstemmed	Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity
title_sort	tailoring the evolution of bl21(de3) uncovers a key role for rna stability in gene expression toxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62bfa52235dd4d8f872de90d6665d3a4
work_keys_str_mv	AT sophiaahheyde tailoringtheevolutionofbl21de3uncoversakeyroleforrnastabilityingeneexpressiontoxicity AT mortenhhnørholm tailoringtheevolutionofbl21de3uncoversakeyroleforrnastabilityingeneexpressiontoxicity
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Tailoring the evolution of BL21(DE3) uncovers a key role for RNA stability in gene expression toxicity

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