The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis

Glucocorticoids are drugs that are widely used to suppress inflammation and the activation of the immune system. However, the prolonged use or at high doses of glucocorticoid can result in adverse side effects including osteoporosis, bone loss, and an increased risk of fracture. A number of compound...

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Autores principales:	Leiming Zhang, Xiaoli Li, Tianhao Ying, Tian Wang, Fenghua Fu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	glucocorticoid-induced osteoporosis herb medicine escin ginsenoside glycyrrhizic acid icariin Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/62c13db280bf47a28dd62c773c469a89
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spelling	oai:doaj.org-article:62c13db280bf47a28dd62c773c469a892021-11-12T13:14:06ZThe Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis1664-239210.3389/fendo.2021.744647https://doaj.org/article/62c13db280bf47a28dd62c773c469a892021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.744647/fullhttps://doaj.org/toc/1664-2392Glucocorticoids are drugs that are widely used to suppress inflammation and the activation of the immune system. However, the prolonged use or at high doses of glucocorticoid can result in adverse side effects including osteoporosis, bone loss, and an increased risk of fracture. A number of compounds derived from natural plant sources have been reported to exert anti-inflammatory activity by interacting with the glucocorticoid receptor (GR), likely owing to their chemical similarity to glucocorticoids, or by regulating GR, without a concomitant risk of treatment-related side effects such as osteoporosis. Other herbal compounds can counteract the pathogenic processes underlying glucocorticoid-induced osteoporosis (GIOP) by regulating homeostatic bone metabolic processes. Herein, we systematically searched the PubMed, Embase, and Cochrane library databases to identify articles discussing such compounds published as of May 01, 2021. Compounds reported to exert anti-inflammatory glucocorticoid-like activity without inducing GIOP include escin, ginsenosides, and glycyrrhizic acid, while compounds reported to alleviate GIOP by improving osteoblast function or modulating steroid hormone synthesis include tanshinol and icariin.Leiming ZhangXiaoli LiTianhao YingTian WangFenghua FuFrontiers Media S.A.articleglucocorticoid-induced osteoporosisherb medicineescinginsenosideglycyrrhizic acidicariinDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glucocorticoid-induced osteoporosis herb medicine escin ginsenoside glycyrrhizic acid icariin Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	glucocorticoid-induced osteoporosis herb medicine escin ginsenoside glycyrrhizic acid icariin Diseases of the endocrine glands. Clinical endocrinology RC648-665 Leiming Zhang Xiaoli Li Tianhao Ying Tian Wang Fenghua Fu The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
description	Glucocorticoids are drugs that are widely used to suppress inflammation and the activation of the immune system. However, the prolonged use or at high doses of glucocorticoid can result in adverse side effects including osteoporosis, bone loss, and an increased risk of fracture. A number of compounds derived from natural plant sources have been reported to exert anti-inflammatory activity by interacting with the glucocorticoid receptor (GR), likely owing to their chemical similarity to glucocorticoids, or by regulating GR, without a concomitant risk of treatment-related side effects such as osteoporosis. Other herbal compounds can counteract the pathogenic processes underlying glucocorticoid-induced osteoporosis (GIOP) by regulating homeostatic bone metabolic processes. Herein, we systematically searched the PubMed, Embase, and Cochrane library databases to identify articles discussing such compounds published as of May 01, 2021. Compounds reported to exert anti-inflammatory glucocorticoid-like activity without inducing GIOP include escin, ginsenosides, and glycyrrhizic acid, while compounds reported to alleviate GIOP by improving osteoblast function or modulating steroid hormone synthesis include tanshinol and icariin.
format	article
author	Leiming Zhang Xiaoli Li Tianhao Ying Tian Wang Fenghua Fu
author_facet	Leiming Zhang Xiaoli Li Tianhao Ying Tian Wang Fenghua Fu
author_sort	Leiming Zhang
title	The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
title_short	The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
title_full	The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
title_fullStr	The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
title_full_unstemmed	The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
title_sort	use of herbal medicines for the prevention of glucocorticoid-induced osteoporosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/62c13db280bf47a28dd62c773c469a89
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The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis

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