Transcranial focused ultrasound phase correction using the hybrid angular spectrum method

Abstract The InSightec Exablate system is the standard of care used for transcranial focused ultrasound ablation treatments in the United States. The system calculates phase corrections that account for aberrations caused by the human skull. This work investigates whether skull aberration correction...

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Autores principales:	Steven A. Leung, David Moore, Taylor D. Webb, John Snell, Pejman Ghanouni, Kim Butts Pauly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62c1998b729b493a902d7a5843c6d19c
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spelling	oai:doaj.org-article:62c1998b729b493a902d7a5843c6d19c2021-12-02T11:45:04ZTranscranial focused ultrasound phase correction using the hybrid angular spectrum method10.1038/s41598-021-85535-52045-2322https://doaj.org/article/62c1998b729b493a902d7a5843c6d19c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85535-5https://doaj.org/toc/2045-2322Abstract The InSightec Exablate system is the standard of care used for transcranial focused ultrasound ablation treatments in the United States. The system calculates phase corrections that account for aberrations caused by the human skull. This work investigates whether skull aberration correction can be improved by comparing the standard of care InSightec ray tracing method with the hybrid angular spectrum (HAS) method and the gold standard hydrophone method. Three degassed ex vivo human skulls were sonicated with a 670 kHz hemispherical phased array transducer (InSightec Exablate 4000). Phase corrections were calculated using four different methods (straight ray tracing, InSightec ray tracing, HAS, and hydrophone) and were used to drive the transducer. 3D raster scans of the beam profiles were acquired using a hydrophone mounted on a 3-axis positioner system. Focal spots were evaluated using six metrics: pressure at the target, peak pressure, intensity at the target, peak intensity, positioning error, and focal spot volume. For three skulls, the InSightec ray tracing method achieved 52 ± 21% normalized target intensity (normalized to hydrophone), 76 ± 17% normalized peak intensity, and 0.72 ± 0.47 mm positioning error. The HAS method achieved 74 ± 9% normalized target intensity, 81 ± 9% normalized peak intensity, and 0.35 ± 0.09 mm positioning error. The InSightec-to-HAS improvement in focal spot targeting provides promise in improving treatment outcomes. These improvements to skull aberration correction are also highly relevant for the applications of focused ultrasound neuromodulation and blood brain barrier opening, which are currently being translated for human use.Steven A. LeungDavid MooreTaylor D. WebbJohn SnellPejman GhanouniKim Butts PaulyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Steven A. Leung David Moore Taylor D. Webb John Snell Pejman Ghanouni Kim Butts Pauly Transcranial focused ultrasound phase correction using the hybrid angular spectrum method
description	Abstract The InSightec Exablate system is the standard of care used for transcranial focused ultrasound ablation treatments in the United States. The system calculates phase corrections that account for aberrations caused by the human skull. This work investigates whether skull aberration correction can be improved by comparing the standard of care InSightec ray tracing method with the hybrid angular spectrum (HAS) method and the gold standard hydrophone method. Three degassed ex vivo human skulls were sonicated with a 670 kHz hemispherical phased array transducer (InSightec Exablate 4000). Phase corrections were calculated using four different methods (straight ray tracing, InSightec ray tracing, HAS, and hydrophone) and were used to drive the transducer. 3D raster scans of the beam profiles were acquired using a hydrophone mounted on a 3-axis positioner system. Focal spots were evaluated using six metrics: pressure at the target, peak pressure, intensity at the target, peak intensity, positioning error, and focal spot volume. For three skulls, the InSightec ray tracing method achieved 52 ± 21% normalized target intensity (normalized to hydrophone), 76 ± 17% normalized peak intensity, and 0.72 ± 0.47 mm positioning error. The HAS method achieved 74 ± 9% normalized target intensity, 81 ± 9% normalized peak intensity, and 0.35 ± 0.09 mm positioning error. The InSightec-to-HAS improvement in focal spot targeting provides promise in improving treatment outcomes. These improvements to skull aberration correction are also highly relevant for the applications of focused ultrasound neuromodulation and blood brain barrier opening, which are currently being translated for human use.
format	article
author	Steven A. Leung David Moore Taylor D. Webb John Snell Pejman Ghanouni Kim Butts Pauly
author_facet	Steven A. Leung David Moore Taylor D. Webb John Snell Pejman Ghanouni Kim Butts Pauly
author_sort	Steven A. Leung
title	Transcranial focused ultrasound phase correction using the hybrid angular spectrum method
title_short	Transcranial focused ultrasound phase correction using the hybrid angular spectrum method
title_full	Transcranial focused ultrasound phase correction using the hybrid angular spectrum method
title_fullStr	Transcranial focused ultrasound phase correction using the hybrid angular spectrum method
title_full_unstemmed	Transcranial focused ultrasound phase correction using the hybrid angular spectrum method
title_sort	transcranial focused ultrasound phase correction using the hybrid angular spectrum method
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62c1998b729b493a902d7a5843c6d19c
work_keys_str_mv	AT stevenaleung transcranialfocusedultrasoundphasecorrectionusingthehybridangularspectrummethod AT davidmoore transcranialfocusedultrasoundphasecorrectionusingthehybridangularspectrummethod AT taylordwebb transcranialfocusedultrasoundphasecorrectionusingthehybridangularspectrummethod AT johnsnell transcranialfocusedultrasoundphasecorrectionusingthehybridangularspectrummethod AT pejmanghanouni transcranialfocusedultrasoundphasecorrectionusingthehybridangularspectrummethod AT kimbuttspauly transcranialfocusedultrasoundphasecorrectionusingthehybridangularspectrummethod
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Transcranial focused ultrasound phase correction using the hybrid angular spectrum method

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