Low digit ratio 2D:4D in alcohol dependent patients.

The ratio of the lengths of the second and fourth finger (2D∶4D) has been described as reflecting the degree of prenatal androgen exposure in humans. 2D∶4D is smaller for males than females and is associated with traits such as left-handedness, physical aggression, attention-deficit-hyperactivity di...

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Autores principales:	Johannes Kornhuber, Gabriele Erhard, Bernd Lenz, Thomas Kraus, Wolfgang Sperling, Kristina Bayerlein, Teresa Biermann, Christina Stoessel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62c4b58d3be84b6fa04a6b8266665dd0
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spelling	oai:doaj.org-article:62c4b58d3be84b6fa04a6b8266665dd02021-11-18T06:55:14ZLow digit ratio 2D:4D in alcohol dependent patients.1932-620310.1371/journal.pone.0019332https://doaj.org/article/62c4b58d3be84b6fa04a6b8266665dd02011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21547078/?tool=EBIhttps://doaj.org/toc/1932-6203The ratio of the lengths of the second and fourth finger (2D∶4D) has been described as reflecting the degree of prenatal androgen exposure in humans. 2D∶4D is smaller for males than females and is associated with traits such as left-handedness, physical aggression, attention-deficit-hyperactivity disorder and a genetic polymorphism of the androgen receptor. All of these traits are known to be correlated to the vulnerability for alcohol dependency. We therefore hypothesized low 2D∶4D in patients with alcohol dependency. In the present study on 131 patients suffering from alcohol dependency and 185 healthy volunteers, we found that alcohol dependent patients had smaller 2D∶4D ratios compared to controls with preserved sexual dimorphism but with reduced right-left differences. The detection of alcohol dependency based on 2D∶4D ratios was most accurate using the right hand of males (ROC-analysis: AUC 0.725, sensitivity 0.667, specificity 0.723). These findings provide novel insights into the role of prenatal androgen exposure in the development of alcohol dependency and for the use of 2D∶4D as a possible trait marker in identifying patients with alcohol dependency.Johannes KornhuberGabriele ErhardBernd LenzThomas KrausWolfgang SperlingKristina BayerleinTeresa BiermannChristina StoesselPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e19332 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johannes Kornhuber Gabriele Erhard Bernd Lenz Thomas Kraus Wolfgang Sperling Kristina Bayerlein Teresa Biermann Christina Stoessel Low digit ratio 2D:4D in alcohol dependent patients.
description	The ratio of the lengths of the second and fourth finger (2D∶4D) has been described as reflecting the degree of prenatal androgen exposure in humans. 2D∶4D is smaller for males than females and is associated with traits such as left-handedness, physical aggression, attention-deficit-hyperactivity disorder and a genetic polymorphism of the androgen receptor. All of these traits are known to be correlated to the vulnerability for alcohol dependency. We therefore hypothesized low 2D∶4D in patients with alcohol dependency. In the present study on 131 patients suffering from alcohol dependency and 185 healthy volunteers, we found that alcohol dependent patients had smaller 2D∶4D ratios compared to controls with preserved sexual dimorphism but with reduced right-left differences. The detection of alcohol dependency based on 2D∶4D ratios was most accurate using the right hand of males (ROC-analysis: AUC 0.725, sensitivity 0.667, specificity 0.723). These findings provide novel insights into the role of prenatal androgen exposure in the development of alcohol dependency and for the use of 2D∶4D as a possible trait marker in identifying patients with alcohol dependency.
format	article
author	Johannes Kornhuber Gabriele Erhard Bernd Lenz Thomas Kraus Wolfgang Sperling Kristina Bayerlein Teresa Biermann Christina Stoessel
author_facet	Johannes Kornhuber Gabriele Erhard Bernd Lenz Thomas Kraus Wolfgang Sperling Kristina Bayerlein Teresa Biermann Christina Stoessel
author_sort	Johannes Kornhuber
title	Low digit ratio 2D:4D in alcohol dependent patients.
title_short	Low digit ratio 2D:4D in alcohol dependent patients.
title_full	Low digit ratio 2D:4D in alcohol dependent patients.
title_fullStr	Low digit ratio 2D:4D in alcohol dependent patients.
title_full_unstemmed	Low digit ratio 2D:4D in alcohol dependent patients.
title_sort	low digit ratio 2d:4d in alcohol dependent patients.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/62c4b58d3be84b6fa04a6b8266665dd0
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Low digit ratio 2D:4D in alcohol dependent patients.

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