Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility

As biodegradable orthopedic implant materials, magnesium alloys have been attracted enough attentions recently. However, too fast degradation in vivo, limited biocompatibilities, and insufficient antibacterial properties are three main challenges at present. In order to solve these problems, a multi...

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Autores principales:	Zhang Qiuyang, Zhang Li, Yang Minhui, Hong Qingxiang, Yang Zhongmei, Liu Sen, Xiong Qingping, Pan Changjiang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	magnesium alloy multifunctional composite coatings corrosion resistance biocompatibilities antibacterial properties Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/62c541c8ae2544739b2db5355a7b934e
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spelling	oai:doaj.org-article:62c541c8ae2544739b2db5355a7b934e2021-12-05T14:10:58ZConstruction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility2191-909710.1515/ntrev-2021-0063https://doaj.org/article/62c541c8ae2544739b2db5355a7b934e2021-08-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0063https://doaj.org/toc/2191-9097As biodegradable orthopedic implant materials, magnesium alloys have been attracted enough attentions recently. However, too fast degradation in vivo, limited biocompatibilities, and insufficient antibacterial properties are three main challenges at present. In order to solve these problems, a multifunctional composite coating of Chi(Zn/BMP2)/HA was constructed on AZ31B magnesium alloy surface, successively by the alkali heating treatment, self-assembly of 16-phosphonyl-hexadecanoic acid, in situ immobilization of Chi(Zn/BMP2) (chitosan, zinc ions, and bone morphogenetic protein 2), and the deposition of HA (hydroxyapatite). The results of ATR-FTIR (attenuated total reflection Fourier transform infrared spectrum) spectra and elemental compositions confirmed that 16-phosphonyl-hexadecanoic acid, Chi(Zn/BMP2), and HA were successfully immobilized on the surface. Compared with Mg, Mg-OH, Mg-16, and Mg-Chi(Zn/BMP2), Mg-Chi(Zn/BMP2)/HA with the concave–convex structure surface significantly enhanced the hydrophilicity and corrosion resistance. On the other hand, Mg-Chi(Zn/BMP2)/HA coating also showed excellent biocompatibilities, which not only significantly promoted the osteoblast adhesion and proliferation, but also upregulated ALP and OCN expression of osteoblasts. Furthermore, due to the synergistic antibacterial effect of zinc ions and chitosan, Mg-Chi(Zn/BMP2)/HA showed a good antibacterial property against Escherichia coli (E. coli). Therefore, it can be said that the method used in this work has a good application prospect in improving the corrosion resistance, biocompatibility of magnesium alloys, and inhibiting infections against E. coli.Zhang QiuyangZhang LiYang MinhuiHong QingxiangYang ZhongmeiLiu SenXiong QingpingPan ChangjiangDe Gruyterarticlemagnesium alloymultifunctional composite coatingscorrosion resistancebiocompatibilitiesantibacterial propertiesTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 870-882 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnesium alloy multifunctional composite coatings corrosion resistance biocompatibilities antibacterial properties Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	magnesium alloy multifunctional composite coatings corrosion resistance biocompatibilities antibacterial properties Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Zhang Qiuyang Zhang Li Yang Minhui Hong Qingxiang Yang Zhongmei Liu Sen Xiong Qingping Pan Changjiang Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
description	As biodegradable orthopedic implant materials, magnesium alloys have been attracted enough attentions recently. However, too fast degradation in vivo, limited biocompatibilities, and insufficient antibacterial properties are three main challenges at present. In order to solve these problems, a multifunctional composite coating of Chi(Zn/BMP2)/HA was constructed on AZ31B magnesium alloy surface, successively by the alkali heating treatment, self-assembly of 16-phosphonyl-hexadecanoic acid, in situ immobilization of Chi(Zn/BMP2) (chitosan, zinc ions, and bone morphogenetic protein 2), and the deposition of HA (hydroxyapatite). The results of ATR-FTIR (attenuated total reflection Fourier transform infrared spectrum) spectra and elemental compositions confirmed that 16-phosphonyl-hexadecanoic acid, Chi(Zn/BMP2), and HA were successfully immobilized on the surface. Compared with Mg, Mg-OH, Mg-16, and Mg-Chi(Zn/BMP2), Mg-Chi(Zn/BMP2)/HA with the concave–convex structure surface significantly enhanced the hydrophilicity and corrosion resistance. On the other hand, Mg-Chi(Zn/BMP2)/HA coating also showed excellent biocompatibilities, which not only significantly promoted the osteoblast adhesion and proliferation, but also upregulated ALP and OCN expression of osteoblasts. Furthermore, due to the synergistic antibacterial effect of zinc ions and chitosan, Mg-Chi(Zn/BMP2)/HA showed a good antibacterial property against Escherichia coli (E. coli). Therefore, it can be said that the method used in this work has a good application prospect in improving the corrosion resistance, biocompatibility of magnesium alloys, and inhibiting infections against E. coli.
format	article
author	Zhang Qiuyang Zhang Li Yang Minhui Hong Qingxiang Yang Zhongmei Liu Sen Xiong Qingping Pan Changjiang
author_facet	Zhang Qiuyang Zhang Li Yang Minhui Hong Qingxiang Yang Zhongmei Liu Sen Xiong Qingping Pan Changjiang
author_sort	Zhang Qiuyang
title	Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
title_short	Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
title_full	Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
title_fullStr	Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
title_full_unstemmed	Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
title_sort	construction of chi(zn/bmp2)/ha composite coating on az31b magnesium alloy surface to improve the corrosion resistance and biocompatibility
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/62c541c8ae2544739b2db5355a7b934e
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Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility

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