The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice.

The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice.

<h4>Background</h4>MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. We previously...

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Main Authors: Neri Mercatelli, Valeria Coppola, Desirée Bonci, Francesca Miele, Arianna Costantini, Marco Guadagnoli, Elena Bonanno, Giovanni Muto, Giovanni Vanni Frajese, Ruggero De Maria, Luigi Giusto Spagnoli, Maria Giulia Farace, Silvia Anna Ciafrè
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2008
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/62cb84e6174e43b3b3b5c72a93f37f58
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https://doaj.org/article/62cb84e6174e43b3b3b5c72a93f37f58

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