Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India

Introduction: CKD5D is a high risk subgroup with high comorbidity burden, need for frequent visits to dialysis centre and a compromised immune system. The effect of SARS COV2 virus on this population is not well known. Methods: This prospective study enrolled, all CKD5D with COVID 19 infection, admi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Smriti Sinha, Rudramani Swami, Ahmad Shakir, Sayed Salman Ali, Jyoti Bansode, Kalpana Mehta
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	covid 19 dialysis end stage renal disease india Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/62cf2a8645b7415698404b061d1cb408
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62cf2a8645b7415698404b061d1cb408
record_format	dspace
spelling	oai:doaj.org-article:62cf2a8645b7415698404b061d1cb4082021-12-02T17:49:11ZClinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India0971-40651998-366210.4103/ijn.IJN_377_20https://doaj.org/article/62cf2a8645b7415698404b061d1cb4082021-01-01T00:00:00Zhttp://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=5;spage=442;epage=448;aulast=Sinhahttps://doaj.org/toc/0971-4065https://doaj.org/toc/1998-3662Introduction: CKD5D is a high risk subgroup with high comorbidity burden, need for frequent visits to dialysis centre and a compromised immune system. The effect of SARS COV2 virus on this population is not well known. Methods: This prospective study enrolled, all CKD5D with COVID 19 infection, admitted to our hospital, from 23rd April to 30th June 2020 & whose outcome as discharge/mortality was known. Their clinical profile, investigations, treatment and outcome in terms of mortality or discharge after clearing infection was noted and analysed. Results: Total 203 dialysis patients with COVID 19 were referred to our institute. Of these total, 131 were analysed. Median age was 50 years (19-80 years) with 57% were males. Hypertension (76%) was the commonest comorbidity followed by diabetes (29%) and coronary artery disease (22%). Dyspnoea, fever and cough were present in 50%, 40%, and 33% patients respectively. 26% were asymptomatic. None had dialyser clotting. Mortality was 20.6%. Time to turn RT PCR negative was 14 days (3-40 days). Comparing deceased vs survivors: Age [56 vs 49 yrs], diabetes [56% vs 22%], duration of symptoms at admission [5 vs 4 days], dyspnea [85% vs 40%] and encephalopathy [30% vs 1%] at admission, bilateral opacities on Chest X ray [93% vs 20%] and high leucocyte count [11,059 ± 5,929 vs 7,022 ± 2,935/cmm] were statistically significant variables associated with mortality. Conclusion: Asymptomatic group was 26% of the total CKD5D with COVID 19 infection population analysed. Mortality was 20.61%. Higher age, later presentation to hospital, diabetes, dyspnoea, & encephalopathy at presentation, bilateral opacities on Chest X- Ray & higher leukocyte counts were significantly associated with mortality.Smriti SinhaRudramani SwamiAhmad ShakirSayed Salman AliJyoti BansodeKalpana MehtaWolters Kluwer Medknow Publicationsarticlecovid 19dialysisend stage renal diseaseindiaDiseases of the genitourinary system. UrologyRC870-923ENIndian Journal of Nephrology, Vol 31, Iss 5, Pp 442-448 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid 19 dialysis end stage renal disease india Diseases of the genitourinary system. Urology RC870-923
spellingShingle	covid 19 dialysis end stage renal disease india Diseases of the genitourinary system. Urology RC870-923 Smriti Sinha Rudramani Swami Ahmad Shakir Sayed Salman Ali Jyoti Bansode Kalpana Mehta Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India
description	Introduction: CKD5D is a high risk subgroup with high comorbidity burden, need for frequent visits to dialysis centre and a compromised immune system. The effect of SARS COV2 virus on this population is not well known. Methods: This prospective study enrolled, all CKD5D with COVID 19 infection, admitted to our hospital, from 23rd April to 30th June 2020 & whose outcome as discharge/mortality was known. Their clinical profile, investigations, treatment and outcome in terms of mortality or discharge after clearing infection was noted and analysed. Results: Total 203 dialysis patients with COVID 19 were referred to our institute. Of these total, 131 were analysed. Median age was 50 years (19-80 years) with 57% were males. Hypertension (76%) was the commonest comorbidity followed by diabetes (29%) and coronary artery disease (22%). Dyspnoea, fever and cough were present in 50%, 40%, and 33% patients respectively. 26% were asymptomatic. None had dialyser clotting. Mortality was 20.6%. Time to turn RT PCR negative was 14 days (3-40 days). Comparing deceased vs survivors: Age [56 vs 49 yrs], diabetes [56% vs 22%], duration of symptoms at admission [5 vs 4 days], dyspnea [85% vs 40%] and encephalopathy [30% vs 1%] at admission, bilateral opacities on Chest X ray [93% vs 20%] and high leucocyte count [11,059 ± 5,929 vs 7,022 ± 2,935/cmm] were statistically significant variables associated with mortality. Conclusion: Asymptomatic group was 26% of the total CKD5D with COVID 19 infection population analysed. Mortality was 20.61%. Higher age, later presentation to hospital, diabetes, dyspnoea, & encephalopathy at presentation, bilateral opacities on Chest X- Ray & higher leukocyte counts were significantly associated with mortality.
format	article
author	Smriti Sinha Rudramani Swami Ahmad Shakir Sayed Salman Ali Jyoti Bansode Kalpana Mehta
author_facet	Smriti Sinha Rudramani Swami Ahmad Shakir Sayed Salman Ali Jyoti Bansode Kalpana Mehta
author_sort	Smriti Sinha
title	Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India
title_short	Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India
title_full	Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India
title_fullStr	Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India
title_full_unstemmed	Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India
title_sort	clinical profile and outcome of hemodialysis patients with sars cov2 infection in a tertiary care centre in mumbai, india
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/62cf2a8645b7415698404b061d1cb408
work_keys_str_mv	AT smritisinha clinicalprofileandoutcomeofhemodialysispatientswithsarscov2infectioninatertiarycarecentreinmumbaiindia AT rudramaniswami clinicalprofileandoutcomeofhemodialysispatientswithsarscov2infectioninatertiarycarecentreinmumbaiindia AT ahmadshakir clinicalprofileandoutcomeofhemodialysispatientswithsarscov2infectioninatertiarycarecentreinmumbaiindia AT sayedsalmanali clinicalprofileandoutcomeofhemodialysispatientswithsarscov2infectioninatertiarycarecentreinmumbaiindia AT jyotibansode clinicalprofileandoutcomeofhemodialysispatientswithsarscov2infectioninatertiarycarecentreinmumbaiindia AT kalpanamehta clinicalprofileandoutcomeofhemodialysispatientswithsarscov2infectioninatertiarycarecentreinmumbaiindia
_version_	1718379469647904768

Clinical profile and outcome of hemodialysis patients with SARS COV2 infection in a tertiary care centre in Mumbai, India

Ejemplares similares