Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

Background: although high-density lipoprotein has cardioprotective effects, the association between serum high-density lipoprotein cholesterol (HDL-C) and hypertension is poorly understood. Therefore, we investigated whether high and low concentrations of HDL-C are associated with high blood pressur...

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Autores principales:	Kei Nakajima, Manami Igata, Ryoko Higuchi, Kotone Tanaka, Kaori Mizusawa, Teiji Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	high-density lipoprotein cholesterol hypertension blood pressure low high-density lipoprotein cholesterol extremely high high-density lipoprotein cholesterol body mass index Medicine R
Acceso en línea:	https://doaj.org/article/62cf8aa043564e57b4d92ee2d40380f8
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spelling	oai:doaj.org-article:62cf8aa043564e57b4d92ee2d40380f82021-11-11T17:44:16ZAssociation of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)10.3390/jcm102151182077-0383https://doaj.org/article/62cf8aa043564e57b4d92ee2d40380f82021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5118https://doaj.org/toc/2077-0383Background: although high-density lipoprotein has cardioprotective effects, the association between serum high-density lipoprotein cholesterol (HDL-C) and hypertension is poorly understood. Therefore, we investigated whether high and low concentrations of HDL-C are associated with high blood pressure (HBP) using a large healthcare dataset. Methods: in a community-based cross-sectional study of 1,493,152 Japanese people (830,669 men and 662,483 women) aged 40–74 years who underwent a health checkup, blood pressures automatically measured at healthcare center were investigated in nine HDL-C groups (20–110 mg/dL or over). Results: crude U-shaped relationship were observed between the nine HDL-C and blood pressures in both men and women. Logistic regression analysis showed left-to-right inverted J-shaped relationships between HDL-C and odds ratios for HBP (≥140/90 mmHg and/or pharmacotherapy), with lower limits of 90–99 mg/dL in both sexes, which were unchanged after adjusting for confounding factors. However, further adjustment for body mass index and serum triglyceride concentration revealed positive linear associations between HDL-C and HBP, although blunt U-shaped associations remained in nonalcohol drinkers. Conclusion: both low and extremely high HDL-C concentrations are associated with HBP. The former association might be dependent on excess fat mass concomitant with low HDL-C, whereas the latter association may be largely dependent on frequent alcohol consumption.Kei NakajimaManami IgataRyoko HiguchiKotone TanakaKaori MizusawaTeiji NakamuraMDPI AGarticlehigh-density lipoprotein cholesterolhypertensionblood pressurelow high-density lipoprotein cholesterolextremely high high-density lipoprotein cholesterolbody mass indexMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5118, p 5118 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	high-density lipoprotein cholesterol hypertension blood pressure low high-density lipoprotein cholesterol extremely high high-density lipoprotein cholesterol body mass index Medicine R
spellingShingle	high-density lipoprotein cholesterol hypertension blood pressure low high-density lipoprotein cholesterol extremely high high-density lipoprotein cholesterol body mass index Medicine R Kei Nakajima Manami Igata Ryoko Higuchi Kotone Tanaka Kaori Mizusawa Teiji Nakamura Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)
description	Background: although high-density lipoprotein has cardioprotective effects, the association between serum high-density lipoprotein cholesterol (HDL-C) and hypertension is poorly understood. Therefore, we investigated whether high and low concentrations of HDL-C are associated with high blood pressure (HBP) using a large healthcare dataset. Methods: in a community-based cross-sectional study of 1,493,152 Japanese people (830,669 men and 662,483 women) aged 40–74 years who underwent a health checkup, blood pressures automatically measured at healthcare center were investigated in nine HDL-C groups (20–110 mg/dL or over). Results: crude U-shaped relationship were observed between the nine HDL-C and blood pressures in both men and women. Logistic regression analysis showed left-to-right inverted J-shaped relationships between HDL-C and odds ratios for HBP (≥140/90 mmHg and/or pharmacotherapy), with lower limits of 90–99 mg/dL in both sexes, which were unchanged after adjusting for confounding factors. However, further adjustment for body mass index and serum triglyceride concentration revealed positive linear associations between HDL-C and HBP, although blunt U-shaped associations remained in nonalcohol drinkers. Conclusion: both low and extremely high HDL-C concentrations are associated with HBP. The former association might be dependent on excess fat mass concomitant with low HDL-C, whereas the latter association may be largely dependent on frequent alcohol consumption.
format	article
author	Kei Nakajima Manami Igata Ryoko Higuchi Kotone Tanaka Kaori Mizusawa Teiji Nakamura
author_facet	Kei Nakajima Manami Igata Ryoko Higuchi Kotone Tanaka Kaori Mizusawa Teiji Nakamura
author_sort	Kei Nakajima
title	Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)
title_short	Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)
title_full	Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)
title_fullStr	Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)
title_full_unstemmed	Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)
title_sort	association of serum high-density lipoprotein cholesterol with high blood pressures at checkup: results of kanagawa investigation of total checkup data from the national database-9 (kitchen-9)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/62cf8aa043564e57b4d92ee2d40380f8
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Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

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