Thyroid function and IVF outcome for different indications of subfertility

Studies evaluating pregnancy outcomes after assisted reproductive treatment (ART) in women with high-normal (2.5–4.5 mIU/L) thyroid-stimulating hormone (TSH) levels are conflicting, possibly due to different patient charactistics and subfertility indications. The aim of this study was to examine the...

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Autores principales:	C C Repelaer van Driel-Delprat, E W C M van Dam, P M van de Ven, K Aissa, M K ter Haar, Y Feenstra, A de Roos, G Beelen, R Schats, C B Lambalk
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	thyroid-stimulating hormone conventional in vitro fertilization primary subfertility unexplained subfertility live birth rate Reproduction QH471-489 Gynecology and obstetrics RG1-991
Acceso en línea:	https://doi.org/10.1530/RAF-20-0065 https://doaj.org/article/62d0cd4f4c20418e99ae46220e6191a0
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spelling	oai:doaj.org-article:62d0cd4f4c20418e99ae46220e6191a02021-11-16T07:06:28ZThyroid function and IVF outcome for different indications of subfertilityhttps://doi.org/10.1530/RAF-20-00652633-8386https://doaj.org/article/62d0cd4f4c20418e99ae46220e6191a02021-11-01T00:00:00Zhttps://raf.bioscientifica.com/view/journals/raf/2/4/RAF-20-0065.xmlhttps://doaj.org/toc/2633-8386Studies evaluating pregnancy outcomes after assisted reproductive treatment (ART) in women with high-normal (2.5–4.5 mIU/L) thyroid-stimulating hormone (TSH) levels are conflicting, possibly due to different patient charactistics and subfertility indications. The aim of this study was to examine the hypothesis that high-normal compared to low-normal TSH levels are associated with adverse implications for pregnancy outcomes in conventional in vitro fertilization (IVF)- treated women. Therefore, we analyzed retrospectively the characteristics and pregnancy outcomes of 949 subfertile women with TSH 0.3–4.5 mIU/L, treated with conventional IVF between January 2008 and March 2012. Demographic and baseline characteristics were compared between groups of patients based on TSH quartiles, using one-way Anova, Kruskal–Wallis ANOVA and chi-square test. Women with high-normal quartile TSH were significantly more likely to be primary subfertile (P = 0.01), with a higher prevalence of unexplained subfertility and with 15% fewer live births after IVF compared to lower TSH quartiles (P = 0.02). In secondary subfertile women with high-normal TSH, male factor subfertility prevailed (P = 0.01), with more live births (P = 0.01). When analyzing primary and secondary subfertile women as one group, these differences failed to be observed, showing no differences in cumulative pregnancy outcomes of IVF between TSH quartiles (I: 0.3–1.21 mIU/L; II: 1.22–1.68 mIU/L; III: 1.69–2.31 mIU/L; IV: 2.32–4.5 mIU/L). In conclusion, primary subfertile women predominate in the high-normal TSH quartile, associated with significantly fewer live births in a subgroup of primary unexplained subfertile women (9%; n = 87/949), while in secondary subfertile women, dominated by male factor subfertility, high-normal TSH is associated with more live births.C C Repelaer van Driel-DelpratE W C M van DamP M van de VenK AissaM K ter HaarY FeenstraA de RoosG BeelenR SchatsC B LambalkBioscientificaarticlethyroid-stimulating hormoneconventional in vitro fertilizationprimary subfertilityunexplained subfertilitylive birth rateReproductionQH471-489Gynecology and obstetricsRG1-991ENReproduction and Fertility, Vol 2, Iss 4, Pp 280-291 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid-stimulating hormone conventional in vitro fertilization primary subfertility unexplained subfertility live birth rate Reproduction QH471-489 Gynecology and obstetrics RG1-991
spellingShingle	thyroid-stimulating hormone conventional in vitro fertilization primary subfertility unexplained subfertility live birth rate Reproduction QH471-489 Gynecology and obstetrics RG1-991 C C Repelaer van Driel-Delprat E W C M van Dam P M van de Ven K Aissa M K ter Haar Y Feenstra A de Roos G Beelen R Schats C B Lambalk Thyroid function and IVF outcome for different indications of subfertility
description	Studies evaluating pregnancy outcomes after assisted reproductive treatment (ART) in women with high-normal (2.5–4.5 mIU/L) thyroid-stimulating hormone (TSH) levels are conflicting, possibly due to different patient charactistics and subfertility indications. The aim of this study was to examine the hypothesis that high-normal compared to low-normal TSH levels are associated with adverse implications for pregnancy outcomes in conventional in vitro fertilization (IVF)- treated women. Therefore, we analyzed retrospectively the characteristics and pregnancy outcomes of 949 subfertile women with TSH 0.3–4.5 mIU/L, treated with conventional IVF between January 2008 and March 2012. Demographic and baseline characteristics were compared between groups of patients based on TSH quartiles, using one-way Anova, Kruskal–Wallis ANOVA and chi-square test. Women with high-normal quartile TSH were significantly more likely to be primary subfertile (P = 0.01), with a higher prevalence of unexplained subfertility and with 15% fewer live births after IVF compared to lower TSH quartiles (P = 0.02). In secondary subfertile women with high-normal TSH, male factor subfertility prevailed (P = 0.01), with more live births (P = 0.01). When analyzing primary and secondary subfertile women as one group, these differences failed to be observed, showing no differences in cumulative pregnancy outcomes of IVF between TSH quartiles (I: 0.3–1.21 mIU/L; II: 1.22–1.68 mIU/L; III: 1.69–2.31 mIU/L; IV: 2.32–4.5 mIU/L). In conclusion, primary subfertile women predominate in the high-normal TSH quartile, associated with significantly fewer live births in a subgroup of primary unexplained subfertile women (9%; n = 87/949), while in secondary subfertile women, dominated by male factor subfertility, high-normal TSH is associated with more live births.
format	article
author	C C Repelaer van Driel-Delprat E W C M van Dam P M van de Ven K Aissa M K ter Haar Y Feenstra A de Roos G Beelen R Schats C B Lambalk
author_facet	C C Repelaer van Driel-Delprat E W C M van Dam P M van de Ven K Aissa M K ter Haar Y Feenstra A de Roos G Beelen R Schats C B Lambalk
author_sort	C C Repelaer van Driel-Delprat
title	Thyroid function and IVF outcome for different indications of subfertility
title_short	Thyroid function and IVF outcome for different indications of subfertility
title_full	Thyroid function and IVF outcome for different indications of subfertility
title_fullStr	Thyroid function and IVF outcome for different indications of subfertility
title_full_unstemmed	Thyroid function and IVF outcome for different indications of subfertility
title_sort	thyroid function and ivf outcome for different indications of subfertility
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/RAF-20-0065 https://doaj.org/article/62d0cd4f4c20418e99ae46220e6191a0
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Thyroid function and IVF outcome for different indications of subfertility

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