The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo

Unpredictable climate change might cause serious lack of food in the world. Therefore, in the present world, it is urgent to prepare countermeasures to solve problems in terms of human survival. In this research, quantitative trait loci (QTLs) were analyzed when rice attacked by white backed plantho...

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Autores principales:	Jae-Ryoung Park, Rahmatullah Jan, Seul-Gi Park, Tri Handoyo, Gang-Seob Lee, Sopheap Yun, Yoon-Hee Jang, Xiao-Xuan Du, Taeho Lee, Yong-Sham Kwon, Doh Hoon Kim, Young-Mi Seok, Jong-Sup Bae, Kyung-Min Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cochlioquinone defense platelet aggregation QTL rice Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/62d3dc7a49704844802ee41fa1079380
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spelling	oai:doaj.org-article:62d3dc7a49704844802ee41fa10793802021-11-25T16:26:19ZThe Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo10.3390/antiox101116912076-3921https://doaj.org/article/62d3dc7a49704844802ee41fa10793802021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1691https://doaj.org/toc/2076-3921Unpredictable climate change might cause serious lack of food in the world. Therefore, in the present world, it is urgent to prepare countermeasures to solve problems in terms of human survival. In this research, quantitative trait loci (QTLs) were analyzed when rice attacked by white backed planthopper (WBPH) were analyzed using 120 Cheongcheong/Nagdong double haploid lines. Moreover, from the detected QTLs, WBPH resistance-related genes were screened in large candidate genes. Among them, <i>OsCM</i>, a major gene in the synthesis of Cochlioquinone-9 (cq-9), was screened. <i>OsCM</i> has high homology with the sequence of chorismate mutase, and exists in various functional and structural forms in plants that produce aromatic amino acids. It also induces resistance to biotic stress through the synthesis of secondary metabolites in plants. The WBPH resistance was improved in rice overexpressed through map-based cloning of the WBPH resistance-related gene <i>OsCM</i>, which was finally detected by QTL mapping. In addition, cq-9 increased the survival rate of caecal ligation puncture (CLP)-surgery mice by 60%. Moreover, the aorta of rat treated with cq-9 was effective in vasodilation response and significantly reduced the aggregation of rat platelets induced by collagen treatment. A cq-9, which is strongly associated with resistance to WBPH in rice, is also associated with positive effect of CLP surgery mice survival rate, vasodilation, and significantly reduced rat platelet aggregation induced by collagen treatment. Therefore, cq-9 presents research possibilities as a substance in a new paradigm that can act on both Plant-Insect in response to the present unpredictable future.Jae-Ryoung ParkRahmatullah JanSeul-Gi ParkTri HandoyoGang-Seob LeeSopheap YunYoon-Hee JangXiao-Xuan DuTaeho LeeYong-Sham KwonDoh Hoon KimYoung-Mi SeokJong-Sup BaeKyung-Min KimMDPI AGarticlecochlioquinonedefenseplatelet aggregationQTLriceTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1691, p 1691 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cochlioquinone defense platelet aggregation QTL rice Therapeutics. Pharmacology RM1-950
spellingShingle	cochlioquinone defense platelet aggregation QTL rice Therapeutics. Pharmacology RM1-950 Jae-Ryoung Park Rahmatullah Jan Seul-Gi Park Tri Handoyo Gang-Seob Lee Sopheap Yun Yoon-Hee Jang Xiao-Xuan Du Taeho Lee Yong-Sham Kwon Doh Hoon Kim Young-Mi Seok Jong-Sup Bae Kyung-Min Kim The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo
description	Unpredictable climate change might cause serious lack of food in the world. Therefore, in the present world, it is urgent to prepare countermeasures to solve problems in terms of human survival. In this research, quantitative trait loci (QTLs) were analyzed when rice attacked by white backed planthopper (WBPH) were analyzed using 120 Cheongcheong/Nagdong double haploid lines. Moreover, from the detected QTLs, WBPH resistance-related genes were screened in large candidate genes. Among them, <i>OsCM</i>, a major gene in the synthesis of Cochlioquinone-9 (cq-9), was screened. <i>OsCM</i> has high homology with the sequence of chorismate mutase, and exists in various functional and structural forms in plants that produce aromatic amino acids. It also induces resistance to biotic stress through the synthesis of secondary metabolites in plants. The WBPH resistance was improved in rice overexpressed through map-based cloning of the WBPH resistance-related gene <i>OsCM</i>, which was finally detected by QTL mapping. In addition, cq-9 increased the survival rate of caecal ligation puncture (CLP)-surgery mice by 60%. Moreover, the aorta of rat treated with cq-9 was effective in vasodilation response and significantly reduced the aggregation of rat platelets induced by collagen treatment. A cq-9, which is strongly associated with resistance to WBPH in rice, is also associated with positive effect of CLP surgery mice survival rate, vasodilation, and significantly reduced rat platelet aggregation induced by collagen treatment. Therefore, cq-9 presents research possibilities as a substance in a new paradigm that can act on both Plant-Insect in response to the present unpredictable future.
format	article
author	Jae-Ryoung Park Rahmatullah Jan Seul-Gi Park Tri Handoyo Gang-Seob Lee Sopheap Yun Yoon-Hee Jang Xiao-Xuan Du Taeho Lee Yong-Sham Kwon Doh Hoon Kim Young-Mi Seok Jong-Sup Bae Kyung-Min Kim
author_facet	Jae-Ryoung Park Rahmatullah Jan Seul-Gi Park Tri Handoyo Gang-Seob Lee Sopheap Yun Yoon-Hee Jang Xiao-Xuan Du Taeho Lee Yong-Sham Kwon Doh Hoon Kim Young-Mi Seok Jong-Sup Bae Kyung-Min Kim
author_sort	Jae-Ryoung Park
title	The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo
title_short	The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo
title_full	The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo
title_fullStr	The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo
title_full_unstemmed	The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo
title_sort	quantitative trait loci mapping of rice plant and the components of its extract confirmed the anti-inflammatory and platelet aggregation effects in vitro and in vivo
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/62d3dc7a49704844802ee41fa1079380
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The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo

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