Two-tiered enforcement of high-fidelity DNA ligation

DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. Here the authors present X-ray structures and kinetic analyses of LIG1 complexes with undamaged and oxidatively damaged DNA that unveil determinants of LIG1 substrate recognition and e...

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Autores principales:	Percy P. Tumbale, Thomas J. Jurkiw, Matthew J. Schellenberg, Amanda A. Riccio, Patrick J O’Brien, R. Scott Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62d68ef04b744353b518a4b33195cafd
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spelling	oai:doaj.org-article:62d68ef04b744353b518a4b33195cafd2021-12-02T16:57:19ZTwo-tiered enforcement of high-fidelity DNA ligation10.1038/s41467-019-13478-72041-1723https://doaj.org/article/62d68ef04b744353b518a4b33195cafd2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13478-7https://doaj.org/toc/2041-1723DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. Here the authors present X-ray structures and kinetic analyses of LIG1 complexes with undamaged and oxidatively damaged DNA that unveil determinants of LIG1 substrate recognition and enzymatic fidelity.Percy P. TumbaleThomas J. JurkiwMatthew J. SchellenbergAmanda A. RiccioPatrick J O’BrienR. Scott WilliamsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Percy P. Tumbale Thomas J. Jurkiw Matthew J. Schellenberg Amanda A. Riccio Patrick J O’Brien R. Scott Williams Two-tiered enforcement of high-fidelity DNA ligation
description	DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. Here the authors present X-ray structures and kinetic analyses of LIG1 complexes with undamaged and oxidatively damaged DNA that unveil determinants of LIG1 substrate recognition and enzymatic fidelity.
format	article
author	Percy P. Tumbale Thomas J. Jurkiw Matthew J. Schellenberg Amanda A. Riccio Patrick J O’Brien R. Scott Williams
author_facet	Percy P. Tumbale Thomas J. Jurkiw Matthew J. Schellenberg Amanda A. Riccio Patrick J O’Brien R. Scott Williams
author_sort	Percy P. Tumbale
title	Two-tiered enforcement of high-fidelity DNA ligation
title_short	Two-tiered enforcement of high-fidelity DNA ligation
title_full	Two-tiered enforcement of high-fidelity DNA ligation
title_fullStr	Two-tiered enforcement of high-fidelity DNA ligation
title_full_unstemmed	Two-tiered enforcement of high-fidelity DNA ligation
title_sort	two-tiered enforcement of high-fidelity dna ligation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/62d68ef04b744353b518a4b33195cafd
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Two-tiered enforcement of high-fidelity DNA ligation

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