The impact of the duration of an untreated episode on improvement of depression and somatic symptoms

Ching-I Hung,1,2 Nan-Wen Yu,1,2 Chia-Yih Liu,1,2 Kuan-Yi Wu,1,2 Ching-Hui Yang3 1Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan, 2Chang Gung University College of Medicine, Tao-Yuan, Taiwan; 3Department of Nursing, Chang Gung University of Science and Technology, Tao-Yuan, T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hung CI, Yu NW, Liu CY, Wu KY, Yang CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/62d9ab81e7e04a0ca0459fe9ec331e3f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:62d9ab81e7e04a0ca0459fe9ec331e3f
record_format	dspace
spelling	oai:doaj.org-article:62d9ab81e7e04a0ca0459fe9ec331e3f2021-12-02T00:32:42ZThe impact of the duration of an untreated episode on improvement of depression and somatic symptoms1178-2021https://doaj.org/article/62d9ab81e7e04a0ca0459fe9ec331e3f2015-08-01T00:00:00Zhttp://www.dovepress.com/the-impact-of-the-duration-of-an-untreated-episode-on-improvement-of-d-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ching-I Hung,1,2 Nan-Wen Yu,1,2 Chia-Yih Liu,1,2 Kuan-Yi Wu,1,2 Ching-Hui Yang3 1Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan, 2Chang Gung University College of Medicine, Tao-Yuan, Taiwan; 3Department of Nursing, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan Purpose: The aim of this study was to investigate the impact of the duration of an untreated episode (DUE) on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD), after the patients had received 4 weeks of pharmacotherapy. Methods: In this open-label study, there were 155 participants with MDD who were treated daily with 75 mg of venlafaxine for 4 weeks. DUE was defined as the interval between the onset of the index major depressive episode and the start of pharmacotherapy. The Depression and Somatic Symptoms Scale (DSSS), composed of the depression subscale (DS) and the somatic subscale (SS), was used. The SS included the pain subscale (PS) and the nonpain somatic subscale (NPSS). Multiple linear regressions were used to test the impacts of DUE on the improvement percentages (IPs) of depression and somatic symptoms. Results: Eighty-five subjects completed the 4-week treatment. The IPs of the DS, SS, and NPSS were significantly negatively correlated with DUE. A shorter DUE was related to higher IPs. DUE was an independent factor, predicting the IPs of the DS, SS, and NPSS. DUE <1 month was the most powerful time-point to predict the IPs of the DS, SS, and NPSS. However, DUE was unable to predict the IP of the PS at all time-points. Conclusion: A shorter DUE might be one of the factors related to greater improvement of depression and somatic symptoms. DUE should be considered as an important factor when investigating the prognosis of depression and somatic symptoms. Keywords: early intervention, somatization, treatment response, prognosis, outcomeHung CIYu NWLiu CYWu KYYang CHDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2245-2252 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hung CI Yu NW Liu CY Wu KY Yang CH The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
description	Ching-I Hung,1,2 Nan-Wen Yu,1,2 Chia-Yih Liu,1,2 Kuan-Yi Wu,1,2 Ching-Hui Yang3 1Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan, 2Chang Gung University College of Medicine, Tao-Yuan, Taiwan; 3Department of Nursing, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan Purpose: The aim of this study was to investigate the impact of the duration of an untreated episode (DUE) on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD), after the patients had received 4 weeks of pharmacotherapy. Methods: In this open-label study, there were 155 participants with MDD who were treated daily with 75 mg of venlafaxine for 4 weeks. DUE was defined as the interval between the onset of the index major depressive episode and the start of pharmacotherapy. The Depression and Somatic Symptoms Scale (DSSS), composed of the depression subscale (DS) and the somatic subscale (SS), was used. The SS included the pain subscale (PS) and the nonpain somatic subscale (NPSS). Multiple linear regressions were used to test the impacts of DUE on the improvement percentages (IPs) of depression and somatic symptoms. Results: Eighty-five subjects completed the 4-week treatment. The IPs of the DS, SS, and NPSS were significantly negatively correlated with DUE. A shorter DUE was related to higher IPs. DUE was an independent factor, predicting the IPs of the DS, SS, and NPSS. DUE <1 month was the most powerful time-point to predict the IPs of the DS, SS, and NPSS. However, DUE was unable to predict the IP of the PS at all time-points. Conclusion: A shorter DUE might be one of the factors related to greater improvement of depression and somatic symptoms. DUE should be considered as an important factor when investigating the prognosis of depression and somatic symptoms. Keywords: early intervention, somatization, treatment response, prognosis, outcome
format	article
author	Hung CI Yu NW Liu CY Wu KY Yang CH
author_facet	Hung CI Yu NW Liu CY Wu KY Yang CH
author_sort	Hung CI
title	The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_short	The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_full	The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_fullStr	The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_full_unstemmed	The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_sort	impact of the duration of an untreated episode on improvement of depression and somatic symptoms
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/62d9ab81e7e04a0ca0459fe9ec331e3f
work_keys_str_mv	AT hungci theimpactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT yunw theimpactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT liucy theimpactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT wuky theimpactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT yangch theimpactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT hungci impactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT yunw impactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT liucy impactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT wuky impactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms AT yangch impactofthedurationofanuntreatedepisodeonimprovementofdepressionandsomaticsymptoms
_version_	1718403679143329792

The impact of the duration of an untreated episode on improvement of depression and somatic symptoms

Ejemplares similares