Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE

Tissue damage and turnover lead to the release of DNA in the blood and can be used to monitor changes in tissue state. Here, the authors developed a tool to accurately estimate the proportion of cell types contributing to cell-free DNA in the blood, with an application to pregnant women and ALS pati...

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Autores principales:	Christa Caggiano, Barbara Celona, Fleur Garton, Joel Mefford, Brian L. Black, Robert Henderson, Catherine Lomen-Hoerth, Andrew Dahl, Noah Zaitlen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62dbc7a6c1794343b7f121153359fe9f
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spelling	oai:doaj.org-article:62dbc7a6c1794343b7f121153359fe9f2021-12-02T17:01:35ZComprehensive cell type decomposition of circulating cell-free DNA with CelFiE10.1038/s41467-021-22901-x2041-1723https://doaj.org/article/62dbc7a6c1794343b7f121153359fe9f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22901-xhttps://doaj.org/toc/2041-1723Tissue damage and turnover lead to the release of DNA in the blood and can be used to monitor changes in tissue state. Here, the authors developed a tool to accurately estimate the proportion of cell types contributing to cell-free DNA in the blood, with an application to pregnant women and ALS patients.Christa CaggianoBarbara CelonaFleur GartonJoel MeffordBrian L. BlackRobert HendersonCatherine Lomen-HoerthAndrew DahlNoah ZaitlenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christa Caggiano Barbara Celona Fleur Garton Joel Mefford Brian L. Black Robert Henderson Catherine Lomen-Hoerth Andrew Dahl Noah Zaitlen Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
description	Tissue damage and turnover lead to the release of DNA in the blood and can be used to monitor changes in tissue state. Here, the authors developed a tool to accurately estimate the proportion of cell types contributing to cell-free DNA in the blood, with an application to pregnant women and ALS patients.
format	article
author	Christa Caggiano Barbara Celona Fleur Garton Joel Mefford Brian L. Black Robert Henderson Catherine Lomen-Hoerth Andrew Dahl Noah Zaitlen
author_facet	Christa Caggiano Barbara Celona Fleur Garton Joel Mefford Brian L. Black Robert Henderson Catherine Lomen-Hoerth Andrew Dahl Noah Zaitlen
author_sort	Christa Caggiano
title	Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
title_short	Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
title_full	Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
title_fullStr	Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
title_full_unstemmed	Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE
title_sort	comprehensive cell type decomposition of circulating cell-free dna with celfie
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62dbc7a6c1794343b7f121153359fe9f
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Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE

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