Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

DNA pairing defects such as mismatched and abasic DNA are prevalent in cancer cells. Here, the authors present luminescent platinum based probes capable of preferentially binding to mismatched and abasic DNA, and reporting this by a significant luminescence enhancement

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Autores principales:	Sin Ki Fung, Taotao Zou, Bei Cao, Tianfeng Chen, Wai-Pong To, Chen Yang, Chun-Nam Lok, Chi-Ming Che
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62dd9cd74bdb4fa18d0acd76382dd53b
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spelling	oai:doaj.org-article:62dd9cd74bdb4fa18d0acd76382dd53b2021-12-02T16:56:47ZLuminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA10.1038/ncomms106552041-1723https://doaj.org/article/62dd9cd74bdb4fa18d0acd76382dd53b2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10655https://doaj.org/toc/2041-1723DNA pairing defects such as mismatched and abasic DNA are prevalent in cancer cells. Here, the authors present luminescent platinum based probes capable of preferentially binding to mismatched and abasic DNA, and reporting this by a significant luminescence enhancementSin Ki FungTaotao ZouBei CaoTianfeng ChenWai-Pong ToChen YangChun-Nam LokChi-Ming CheNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sin Ki Fung Taotao Zou Bei Cao Tianfeng Chen Wai-Pong To Chen Yang Chun-Nam Lok Chi-Ming Che Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA
description	DNA pairing defects such as mismatched and abasic DNA are prevalent in cancer cells. Here, the authors present luminescent platinum based probes capable of preferentially binding to mismatched and abasic DNA, and reporting this by a significant luminescence enhancement
format	article
author	Sin Ki Fung Taotao Zou Bei Cao Tianfeng Chen Wai-Pong To Chen Yang Chun-Nam Lok Chi-Ming Che
author_facet	Sin Ki Fung Taotao Zou Bei Cao Tianfeng Chen Wai-Pong To Chen Yang Chun-Nam Lok Chi-Ming Che
author_sort	Sin Ki Fung
title	Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA
title_short	Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA
title_full	Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA
title_fullStr	Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA
title_full_unstemmed	Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA
title_sort	luminescent platinum(ii) complexes with functionalized n-heterocyclic carbene or diphosphine selectively probe mismatched and abasic dna
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/62dd9cd74bdb4fa18d0acd76382dd53b
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Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

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