Asic3(-/-) female mice with hearing deficit affects social development of pups.

<h4>Background</h4>Infant crying is an important cue for mothers to respond adequately. Inappropriate response to infant crying can hinder social development in infants. In rodents, the pup-mother interaction largely depends on pup's calls. Mouse pups emit high frequency to ultrason...

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Autores principales:	Wei-Li Wu, Chih-Hung Wang, Eagle Yi-Kung Huang, Chih-Cheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62e1fef146a7478fad3211b5060d94b2
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spelling	oai:doaj.org-article:62e1fef146a7478fad3211b5060d94b22021-11-25T06:21:14ZAsic3(-/-) female mice with hearing deficit affects social development of pups.1932-620310.1371/journal.pone.0006508https://doaj.org/article/62e1fef146a7478fad3211b5060d94b22009-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19652708/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Infant crying is an important cue for mothers to respond adequately. Inappropriate response to infant crying can hinder social development in infants. In rodents, the pup-mother interaction largely depends on pup's calls. Mouse pups emit high frequency to ultrasonic vocalization (2-90 kHz) to communicate with their dam for maternal care. However, little is known about how the maternal response to infant crying or pup calls affects social development over the long term.<h4>Methodology/principal findings</h4>Here we used mice lacking acid-sensing ion channel 3 (Asic3(-/-)) to create a hearing deficit to probe the effect of caregiver hearing on maternal care and adolescent social development. Female Asic3(-/-) mice showed elevated hearing thresholds for low to ultrasonic frequency (4-32 kHz) on auditory brain stem response, which thus hindered their response to their pups' wriggling calls and ultrasonic vocalization, as well as their retrieval of pups. In adolescence, pups reared by Asic3(-/-) mice showed a social deficit in juvenile social behaviors as compared with those reared by wild-type or heterozygous dams. The social-deficit phenotype in juvenile mice reared by Asic3(-/-) mice was associated with the reduced serotonin transmission of the brain. However, Asic3(-/-) pups cross-fostered to wild-type dams showed rescued social deficit.<h4>Conclusions/significance</h4>Inadequate response to pups' calls as a result of ASIC3-dependent hearing loss confers maternal deficits in caregivers and social development deficits in their young.Wei-Li WuChih-Hung WangEagle Yi-Kung HuangChih-Cheng ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 8, p e6508 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei-Li Wu Chih-Hung Wang Eagle Yi-Kung Huang Chih-Cheng Chen Asic3(-/-) female mice with hearing deficit affects social development of pups.
description	<h4>Background</h4>Infant crying is an important cue for mothers to respond adequately. Inappropriate response to infant crying can hinder social development in infants. In rodents, the pup-mother interaction largely depends on pup's calls. Mouse pups emit high frequency to ultrasonic vocalization (2-90 kHz) to communicate with their dam for maternal care. However, little is known about how the maternal response to infant crying or pup calls affects social development over the long term.<h4>Methodology/principal findings</h4>Here we used mice lacking acid-sensing ion channel 3 (Asic3(-/-)) to create a hearing deficit to probe the effect of caregiver hearing on maternal care and adolescent social development. Female Asic3(-/-) mice showed elevated hearing thresholds for low to ultrasonic frequency (4-32 kHz) on auditory brain stem response, which thus hindered their response to their pups' wriggling calls and ultrasonic vocalization, as well as their retrieval of pups. In adolescence, pups reared by Asic3(-/-) mice showed a social deficit in juvenile social behaviors as compared with those reared by wild-type or heterozygous dams. The social-deficit phenotype in juvenile mice reared by Asic3(-/-) mice was associated with the reduced serotonin transmission of the brain. However, Asic3(-/-) pups cross-fostered to wild-type dams showed rescued social deficit.<h4>Conclusions/significance</h4>Inadequate response to pups' calls as a result of ASIC3-dependent hearing loss confers maternal deficits in caregivers and social development deficits in their young.
format	article
author	Wei-Li Wu Chih-Hung Wang Eagle Yi-Kung Huang Chih-Cheng Chen
author_facet	Wei-Li Wu Chih-Hung Wang Eagle Yi-Kung Huang Chih-Cheng Chen
author_sort	Wei-Li Wu
title	Asic3(-/-) female mice with hearing deficit affects social development of pups.
title_short	Asic3(-/-) female mice with hearing deficit affects social development of pups.
title_full	Asic3(-/-) female mice with hearing deficit affects social development of pups.
title_fullStr	Asic3(-/-) female mice with hearing deficit affects social development of pups.
title_full_unstemmed	Asic3(-/-) female mice with hearing deficit affects social development of pups.
title_sort	asic3(-/-) female mice with hearing deficit affects social development of pups.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/62e1fef146a7478fad3211b5060d94b2
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Asic3(-/-) female mice with hearing deficit affects social development of pups.

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