Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants

Soft tissue tumors in infants encompass an overlapping spectrum of diseases posing unique diagnostic and clinical challenges. Here, the authors investigate the genetic basis of cryptogenic congenital mesoblastic nephroma and infantile fibrosarcoma lacking the canonical NTRK3-ETV6 fusion gene, and id...

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Autores principales:	Jenny Wegert, Christian Vokuhl, Grace Collord, Martin Del Castillo Velasco-Herrera, Sarah J. Farndon, Charlotte Guzzo, Mette Jorgensen, John Anderson, Olga Slater, Catriona Duncan, Sabrina Bausenwein, Heike Streitenberger, Barbara Ziegler, Rhoikos Furtwängler, Norbert Graf, Michael R. Stratton, Peter J. Campbell, David TW Jones, Christian Koelsche, Stefan M. Pfister, William Mifsud, Neil Sebire, Monika Sparber-Sauer, Ewa Koscielniak, Andreas Rosenwald, Manfred Gessler, Sam Behjati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62e3e5d944664e6c8173d5eb54868ff0
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spelling	oai:doaj.org-article:62e3e5d944664e6c8173d5eb54868ff02021-12-02T16:50:11ZRecurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants10.1038/s41467-018-04650-62041-1723https://doaj.org/article/62e3e5d944664e6c8173d5eb54868ff02018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04650-6https://doaj.org/toc/2041-1723Soft tissue tumors in infants encompass an overlapping spectrum of diseases posing unique diagnostic and clinical challenges. Here, the authors investigate the genetic basis of cryptogenic congenital mesoblastic nephroma and infantile fibrosarcoma lacking the canonical NTRK3-ETV6 fusion gene, and identify therapeutically tractable intragenic rearrangements in EGFR and BRAF.Jenny WegertChristian VokuhlGrace CollordMartin Del Castillo Velasco-HerreraSarah J. FarndonCharlotte GuzzoMette JorgensenJohn AndersonOlga SlaterCatriona DuncanSabrina BausenweinHeike StreitenbergerBarbara ZieglerRhoikos FurtwänglerNorbert GrafMichael R. StrattonPeter J. CampbellDavid TW JonesChristian KoelscheStefan M. PfisterWilliam MifsudNeil SebireMonika Sparber-SauerEwa KoscielniakAndreas RosenwaldManfred GesslerSam BehjatiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jenny Wegert Christian Vokuhl Grace Collord Martin Del Castillo Velasco-Herrera Sarah J. Farndon Charlotte Guzzo Mette Jorgensen John Anderson Olga Slater Catriona Duncan Sabrina Bausenwein Heike Streitenberger Barbara Ziegler Rhoikos Furtwängler Norbert Graf Michael R. Stratton Peter J. Campbell David TW Jones Christian Koelsche Stefan M. Pfister William Mifsud Neil Sebire Monika Sparber-Sauer Ewa Koscielniak Andreas Rosenwald Manfred Gessler Sam Behjati Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants
description	Soft tissue tumors in infants encompass an overlapping spectrum of diseases posing unique diagnostic and clinical challenges. Here, the authors investigate the genetic basis of cryptogenic congenital mesoblastic nephroma and infantile fibrosarcoma lacking the canonical NTRK3-ETV6 fusion gene, and identify therapeutically tractable intragenic rearrangements in EGFR and BRAF.
format	article
author	Jenny Wegert Christian Vokuhl Grace Collord Martin Del Castillo Velasco-Herrera Sarah J. Farndon Charlotte Guzzo Mette Jorgensen John Anderson Olga Slater Catriona Duncan Sabrina Bausenwein Heike Streitenberger Barbara Ziegler Rhoikos Furtwängler Norbert Graf Michael R. Stratton Peter J. Campbell David TW Jones Christian Koelsche Stefan M. Pfister William Mifsud Neil Sebire Monika Sparber-Sauer Ewa Koscielniak Andreas Rosenwald Manfred Gessler Sam Behjati
author_facet	Jenny Wegert Christian Vokuhl Grace Collord Martin Del Castillo Velasco-Herrera Sarah J. Farndon Charlotte Guzzo Mette Jorgensen John Anderson Olga Slater Catriona Duncan Sabrina Bausenwein Heike Streitenberger Barbara Ziegler Rhoikos Furtwängler Norbert Graf Michael R. Stratton Peter J. Campbell David TW Jones Christian Koelsche Stefan M. Pfister William Mifsud Neil Sebire Monika Sparber-Sauer Ewa Koscielniak Andreas Rosenwald Manfred Gessler Sam Behjati
author_sort	Jenny Wegert
title	Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants
title_short	Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants
title_full	Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants
title_fullStr	Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants
title_full_unstemmed	Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants
title_sort	recurrent intragenic rearrangements of egfr and braf in soft tissue tumors of infants
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/62e3e5d944664e6c8173d5eb54868ff0
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Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants

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