Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.

Receptor-like kinases (RLKs) constitute a large family of signal perception molecules in Arabidopsis. The largest group of RLKs is the leucine-rich repeat (LRR) class that has been described to function in development and defense. Of these, CLAVATA1 (CLV1) and ERECTA (ER) receptors function in maint...

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Autores principales:	Colette A ten Hove, Mark de Jong, Dmitry Lapin, Annemiek Andel, Gabino F Sanchez-Perez, Yoshiaki Tarutani, Yoshihito Suzuki, Renze Heidstra, Guido van den Ackerveken
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62e405c9e1d04c7b8395254fbdb8f8d8
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spelling	oai:doaj.org-article:62e405c9e1d04c7b8395254fbdb8f8d82021-11-18T06:55:25ZTrans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.1932-620310.1371/journal.pone.0019028https://doaj.org/article/62e405c9e1d04c7b8395254fbdb8f8d82011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21532992/?tool=EBIhttps://doaj.org/toc/1932-6203Receptor-like kinases (RLKs) constitute a large family of signal perception molecules in Arabidopsis. The largest group of RLKs is the leucine-rich repeat (LRR) class that has been described to function in development and defense. Of these, CLAVATA1 (CLV1) and ERECTA (ER) receptors function in maintaining shoot meristem homeostasis and organ growth, but LRR RLKs with similar function in the root remain unknown. For the interaction of Arabidopsis with the oomycete pathogen Hyaloperonospora arabidopsidis the involvement of LRR RLKs has not been demonstrated. A set of homozygous T-DNA insertion lines mutated in LRR RLKs was investigated to assess the potential role of these receptors in root meristem maintenance and compatibility. One mutant line, rlk902, was discovered that showed both reduced root growth and resistance to downy mildew in a recessive manner. The phenotypes of this mutated line could not be rescued by complementation, but are nevertheless linked to the T-DNA insertion. Microarray studies showed that gene expression spanning a region of approximately 84 kb upstream of the mutated gene was downregulated. The results suggest T-DNA mediated trans-repression of multiple genes upstream of the RLK902 locus links both phenotypes.Colette A ten HoveMark de JongDmitry LapinAnnemiek AndelGabino F Sanchez-PerezYoshiaki TarutaniYoshihito SuzukiRenze HeidstraGuido van den AckervekenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e19028 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Colette A ten Hove Mark de Jong Dmitry Lapin Annemiek Andel Gabino F Sanchez-Perez Yoshiaki Tarutani Yoshihito Suzuki Renze Heidstra Guido van den Ackerveken Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.
description	Receptor-like kinases (RLKs) constitute a large family of signal perception molecules in Arabidopsis. The largest group of RLKs is the leucine-rich repeat (LRR) class that has been described to function in development and defense. Of these, CLAVATA1 (CLV1) and ERECTA (ER) receptors function in maintaining shoot meristem homeostasis and organ growth, but LRR RLKs with similar function in the root remain unknown. For the interaction of Arabidopsis with the oomycete pathogen Hyaloperonospora arabidopsidis the involvement of LRR RLKs has not been demonstrated. A set of homozygous T-DNA insertion lines mutated in LRR RLKs was investigated to assess the potential role of these receptors in root meristem maintenance and compatibility. One mutant line, rlk902, was discovered that showed both reduced root growth and resistance to downy mildew in a recessive manner. The phenotypes of this mutated line could not be rescued by complementation, but are nevertheless linked to the T-DNA insertion. Microarray studies showed that gene expression spanning a region of approximately 84 kb upstream of the mutated gene was downregulated. The results suggest T-DNA mediated trans-repression of multiple genes upstream of the RLK902 locus links both phenotypes.
format	article
author	Colette A ten Hove Mark de Jong Dmitry Lapin Annemiek Andel Gabino F Sanchez-Perez Yoshiaki Tarutani Yoshihito Suzuki Renze Heidstra Guido van den Ackerveken
author_facet	Colette A ten Hove Mark de Jong Dmitry Lapin Annemiek Andel Gabino F Sanchez-Perez Yoshiaki Tarutani Yoshihito Suzuki Renze Heidstra Guido van den Ackerveken
author_sort	Colette A ten Hove
title	Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.
title_short	Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.
title_full	Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.
title_fullStr	Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.
title_full_unstemmed	Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.
title_sort	trans-repression of gene activity upstream of t-dna tagged rlk902 links arabidopsis root growth inhibition and downy mildew resistance.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/62e405c9e1d04c7b8395254fbdb8f8d8
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Trans-repression of gene activity upstream of T-DNA tagged RLK902 links Arabidopsis root growth inhibition and downy mildew resistance.

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