Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report
Background: Main motor characteristics in Parkinson's disease (PD) include bradykinesia, rigidity, and tremors. With the development of neuromodulation techniques, it has become possible to use deep brain stimulation (DBS) to control the symptoms of PD. However, since the subthalamic nucleus(ST...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:62e4b387725c45eb9b6b3178e51e10a42021-12-01T02:42:21ZBilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report1662-453X10.3389/fnins.2021.782046https://doaj.org/article/62e4b387725c45eb9b6b3178e51e10a42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.782046/fullhttps://doaj.org/toc/1662-453XBackground: Main motor characteristics in Parkinson's disease (PD) include bradykinesia, rigidity, and tremors. With the development of neuromodulation techniques, it has become possible to use deep brain stimulation (DBS) to control the symptoms of PD. However, since the subthalamic nucleus(STN) and globus pallidus interna (GPi) DBS have their own advantages and disadvantages, it is difficult to control symptoms of the patients. It is essential to find new stimulation methods.Case Presentation: A 33-year-old male PD patient with onset at the age of 12 years. The onset of the disease is presented with bradykinesia and progressively developed severe choreic dyskinesia with the use of medications. We then performed a thorough evaluation of the patient and decided to perform bilateral globus pallidus interna combined with subthalamic nucleus variable frequency DBS (bSGC-DBS) implantation, and after 2 years of follow-up the patient's bradykinesia and dyskinesia symptoms and quality of life improved significantly.Conclusions: This is the first case of bSCG-DBS in a PD patient with refractory dyskinesia, and the first report of encouraging results from this clinical condition. This important finding explores multi-electrode and multi-target stimulation for the treatment of dystonia disorders.Bowen ChangBowen ChangBowen ChangJiaming MeiJiaming MeiJiaming MeiChi XiongChi XiongChi XiongPeng ChenPeng ChenPeng ChenManli JiangManli JiangManli JiangChaoshi NiuChaoshi NiuChaoshi NiuFrontiers Media S.A.articleParkinson's diseasedyskinesiadeep brain stimulation (DBS)treatmentsubthalamic nucleusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021) |
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| topic |
Parkinson's disease dyskinesia deep brain stimulation (DBS) treatment subthalamic nucleus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
Parkinson's disease dyskinesia deep brain stimulation (DBS) treatment subthalamic nucleus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Bowen Chang Bowen Chang Bowen Chang Jiaming Mei Jiaming Mei Jiaming Mei Chi Xiong Chi Xiong Chi Xiong Peng Chen Peng Chen Peng Chen Manli Jiang Manli Jiang Manli Jiang Chaoshi Niu Chaoshi Niu Chaoshi Niu Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report |
| description |
Background: Main motor characteristics in Parkinson's disease (PD) include bradykinesia, rigidity, and tremors. With the development of neuromodulation techniques, it has become possible to use deep brain stimulation (DBS) to control the symptoms of PD. However, since the subthalamic nucleus(STN) and globus pallidus interna (GPi) DBS have their own advantages and disadvantages, it is difficult to control symptoms of the patients. It is essential to find new stimulation methods.Case Presentation: A 33-year-old male PD patient with onset at the age of 12 years. The onset of the disease is presented with bradykinesia and progressively developed severe choreic dyskinesia with the use of medications. We then performed a thorough evaluation of the patient and decided to perform bilateral globus pallidus interna combined with subthalamic nucleus variable frequency DBS (bSGC-DBS) implantation, and after 2 years of follow-up the patient's bradykinesia and dyskinesia symptoms and quality of life improved significantly.Conclusions: This is the first case of bSCG-DBS in a PD patient with refractory dyskinesia, and the first report of encouraging results from this clinical condition. This important finding explores multi-electrode and multi-target stimulation for the treatment of dystonia disorders. |
| format |
article |
| author |
Bowen Chang Bowen Chang Bowen Chang Jiaming Mei Jiaming Mei Jiaming Mei Chi Xiong Chi Xiong Chi Xiong Peng Chen Peng Chen Peng Chen Manli Jiang Manli Jiang Manli Jiang Chaoshi Niu Chaoshi Niu Chaoshi Niu |
| author_facet |
Bowen Chang Bowen Chang Bowen Chang Jiaming Mei Jiaming Mei Jiaming Mei Chi Xiong Chi Xiong Chi Xiong Peng Chen Peng Chen Peng Chen Manli Jiang Manli Jiang Manli Jiang Chaoshi Niu Chaoshi Niu Chaoshi Niu |
| author_sort |
Bowen Chang |
| title |
Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report |
| title_short |
Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report |
| title_full |
Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report |
| title_fullStr |
Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report |
| title_full_unstemmed |
Bilateral Globus Pallidus Interna Combined With Subthalamic Nucleus Variable Frequency Deep Brain Stimulation in the Treatment of Young-Onset Parkinson's Disease With Refractory Dyskinesia: A Case Report |
| title_sort |
bilateral globus pallidus interna combined with subthalamic nucleus variable frequency deep brain stimulation in the treatment of young-onset parkinson's disease with refractory dyskinesia: a case report |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/62e4b387725c45eb9b6b3178e51e10a4 |
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