Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive

Abstract Mounting an appropriate ventilatory response to exercise is crucial to meeting metabolic demands, and abnormal ventilatory responses may contribute to exercise-intolerance (EX-inT) in heart failure (HF) patients. We sought to determine if abnormal ventilatory chemoreflex control contributes...

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Autores principales:	David C. Andrade, Esteban Díaz-Jara, Camilo Toledo, Karla G. Schwarz, Katherin V. Pereyra, Hugo S. Díaz, Noah J. Marcus, Fernando C. Ortiz, Angélica P. Ríos-Gallardo, Domiziana Ortolani, Rodrigo Del Rio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62e4d1f37bb74895812428713f6a8021
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spelling	oai:doaj.org-article:62e4d1f37bb74895812428713f6a80212021-12-02T15:33:00ZExercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive10.1038/s41598-021-93791-82045-2322https://doaj.org/article/62e4d1f37bb74895812428713f6a80212021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93791-8https://doaj.org/toc/2045-2322Abstract Mounting an appropriate ventilatory response to exercise is crucial to meeting metabolic demands, and abnormal ventilatory responses may contribute to exercise-intolerance (EX-inT) in heart failure (HF) patients. We sought to determine if abnormal ventilatory chemoreflex control contributes to EX-inT in volume-overload HF rats. Cardiac function, hypercapnic (HCVR) and hypoxic (HVR) ventilatory responses, and exercise tolerance were assessed at the end of a 6 week exercise training program. At the conclusion of the training program, exercise tolerant HF rats (HF + EX-T) exhibited improvements in cardiac systolic function and reductions in HCVR, sympathetic tone, and arrhythmias. In contrast, HF rats that were exercise intolerant (HF + EX-inT) exhibited worse diastolic dysfunction, and showed no improvements in cardiac systolic function, HCVR, sympathetic tone, or arrhythmias at the conclusion of the training program. In addition, HF + EX-inT rats had impaired HVR which was associated with increased arrhythmia susceptibility and mortality during hypoxic challenges (~ 60% survival). Finally, we observed that exercise tolerance in HF rats was related to carotid body (CB) function as CB ablation resulted in impaired exercise capacity in HF + EX-T rats. Our results indicate that: (i) exercise may have detrimental effects on cardiac function in HF-EX-inT, and (ii) loss of CB chemoreflex sensitivity contributes to EX-inT in HF.David C. AndradeEsteban Díaz-JaraCamilo ToledoKarla G. SchwarzKatherin V. PereyraHugo S. DíazNoah J. MarcusFernando C. OrtizAngélica P. Ríos-GallardoDomiziana OrtolaniRodrigo Del RioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David C. Andrade Esteban Díaz-Jara Camilo Toledo Karla G. Schwarz Katherin V. Pereyra Hugo S. Díaz Noah J. Marcus Fernando C. Ortiz Angélica P. Ríos-Gallardo Domiziana Ortolani Rodrigo Del Rio Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
description	Abstract Mounting an appropriate ventilatory response to exercise is crucial to meeting metabolic demands, and abnormal ventilatory responses may contribute to exercise-intolerance (EX-inT) in heart failure (HF) patients. We sought to determine if abnormal ventilatory chemoreflex control contributes to EX-inT in volume-overload HF rats. Cardiac function, hypercapnic (HCVR) and hypoxic (HVR) ventilatory responses, and exercise tolerance were assessed at the end of a 6 week exercise training program. At the conclusion of the training program, exercise tolerant HF rats (HF + EX-T) exhibited improvements in cardiac systolic function and reductions in HCVR, sympathetic tone, and arrhythmias. In contrast, HF rats that were exercise intolerant (HF + EX-inT) exhibited worse diastolic dysfunction, and showed no improvements in cardiac systolic function, HCVR, sympathetic tone, or arrhythmias at the conclusion of the training program. In addition, HF + EX-inT rats had impaired HVR which was associated with increased arrhythmia susceptibility and mortality during hypoxic challenges (~ 60% survival). Finally, we observed that exercise tolerance in HF rats was related to carotid body (CB) function as CB ablation resulted in impaired exercise capacity in HF + EX-T rats. Our results indicate that: (i) exercise may have detrimental effects on cardiac function in HF-EX-inT, and (ii) loss of CB chemoreflex sensitivity contributes to EX-inT in HF.
format	article
author	David C. Andrade Esteban Díaz-Jara Camilo Toledo Karla G. Schwarz Katherin V. Pereyra Hugo S. Díaz Noah J. Marcus Fernando C. Ortiz Angélica P. Ríos-Gallardo Domiziana Ortolani Rodrigo Del Rio
author_facet	David C. Andrade Esteban Díaz-Jara Camilo Toledo Karla G. Schwarz Katherin V. Pereyra Hugo S. Díaz Noah J. Marcus Fernando C. Ortiz Angélica P. Ríos-Gallardo Domiziana Ortolani Rodrigo Del Rio
author_sort	David C. Andrade
title	Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
title_short	Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
title_full	Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
title_fullStr	Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
title_full_unstemmed	Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
title_sort	exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62e4d1f37bb74895812428713f6a8021
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Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive

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