Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity

Sleep disturbances are common in post-traumatic stress disorder (PTSD), although which sleep microarchitectural characteristics reliably classify those with and without PTSD remains equivocal. Here, we investigated sleep microarchitectural differences (i.e., spectral power, spindle activity) in trau...

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Autores principales:	Dan Denis, Ryan Bottary, Tony J. Cunningham, Shengzi Zeng, Carolina Daffre, Kaitlyn L. Oliver, Kylie Moore, Samuel Gazecki, Augustus Kram Mendelsohn, Uriel Martinez, Karen Gannon, Natasha B. Lasko, Edward F. Pace-Schott
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	post-traumatic stress disorder sleep spectral power sleep spindles beta power Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/62e966d0c8b34bc1af29aaaa57f7f31f
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spelling	oai:doaj.org-article:62e966d0c8b34bc1af29aaaa57f7f31f2021-11-19T06:33:12ZSleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity1664-064010.3389/fpsyt.2021.766647https://doaj.org/article/62e966d0c8b34bc1af29aaaa57f7f31f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.766647/fullhttps://doaj.org/toc/1664-0640Sleep disturbances are common in post-traumatic stress disorder (PTSD), although which sleep microarchitectural characteristics reliably classify those with and without PTSD remains equivocal. Here, we investigated sleep microarchitectural differences (i.e., spectral power, spindle activity) in trauma-exposed individuals that met (n = 45) or did not meet (n = 52) criteria for PTSD and how these differences relate to post-traumatic and related psychopathological symptoms. Using ecologically-relevant home sleep polysomnography recordings, we show that individuals with PTSD exhibit decreased beta spectral power during NREM sleep and increased fast sleep spindle peak frequencies. Contrary to prior reports, spectral power in the beta frequency range (20.31–29.88 Hz) was associated with reduced PTSD symptoms, reduced depression, anxiety and stress and greater subjective ability to regulate emotions. Increased fast frequency spindle activity was not associated with individual differences in psychopathology. Our findings may suggest an adaptive role for beta power during sleep in individuals exposed to a trauma, potentially conferring resilience. Further, we add to a growing body of evidence that spindle activity may be an important biomarker for studying PTSD pathophysiology.Dan DenisRyan BottaryRyan BottaryRyan BottaryTony J. CunninghamTony J. CunninghamTony J. CunninghamShengzi ZengCarolina DaffreCarolina DaffreKaitlyn L. OliverKaitlyn L. OliverKylie MooreKylie MooreSamuel GazeckiSamuel GazeckiAugustus Kram MendelsohnAugustus Kram MendelsohnUriel MartinezUriel MartinezKaren GannonNatasha B. LaskoNatasha B. LaskoEdward F. Pace-SchottEdward F. Pace-SchottEdward F. Pace-SchottFrontiers Media S.A.articlepost-traumatic stress disordersleepspectral powersleep spindlesbeta powerPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post-traumatic stress disorder sleep spectral power sleep spindles beta power Psychiatry RC435-571
spellingShingle	post-traumatic stress disorder sleep spectral power sleep spindles beta power Psychiatry RC435-571 Dan Denis Ryan Bottary Ryan Bottary Ryan Bottary Tony J. Cunningham Tony J. Cunningham Tony J. Cunningham Shengzi Zeng Carolina Daffre Carolina Daffre Kaitlyn L. Oliver Kaitlyn L. Oliver Kylie Moore Kylie Moore Samuel Gazecki Samuel Gazecki Augustus Kram Mendelsohn Augustus Kram Mendelsohn Uriel Martinez Uriel Martinez Karen Gannon Natasha B. Lasko Natasha B. Lasko Edward F. Pace-Schott Edward F. Pace-Schott Edward F. Pace-Schott Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity
description	Sleep disturbances are common in post-traumatic stress disorder (PTSD), although which sleep microarchitectural characteristics reliably classify those with and without PTSD remains equivocal. Here, we investigated sleep microarchitectural differences (i.e., spectral power, spindle activity) in trauma-exposed individuals that met (n = 45) or did not meet (n = 52) criteria for PTSD and how these differences relate to post-traumatic and related psychopathological symptoms. Using ecologically-relevant home sleep polysomnography recordings, we show that individuals with PTSD exhibit decreased beta spectral power during NREM sleep and increased fast sleep spindle peak frequencies. Contrary to prior reports, spectral power in the beta frequency range (20.31–29.88 Hz) was associated with reduced PTSD symptoms, reduced depression, anxiety and stress and greater subjective ability to regulate emotions. Increased fast frequency spindle activity was not associated with individual differences in psychopathology. Our findings may suggest an adaptive role for beta power during sleep in individuals exposed to a trauma, potentially conferring resilience. Further, we add to a growing body of evidence that spindle activity may be an important biomarker for studying PTSD pathophysiology.
format	article
author	Dan Denis Ryan Bottary Ryan Bottary Ryan Bottary Tony J. Cunningham Tony J. Cunningham Tony J. Cunningham Shengzi Zeng Carolina Daffre Carolina Daffre Kaitlyn L. Oliver Kaitlyn L. Oliver Kylie Moore Kylie Moore Samuel Gazecki Samuel Gazecki Augustus Kram Mendelsohn Augustus Kram Mendelsohn Uriel Martinez Uriel Martinez Karen Gannon Natasha B. Lasko Natasha B. Lasko Edward F. Pace-Schott Edward F. Pace-Schott Edward F. Pace-Schott
author_facet	Dan Denis Ryan Bottary Ryan Bottary Ryan Bottary Tony J. Cunningham Tony J. Cunningham Tony J. Cunningham Shengzi Zeng Carolina Daffre Carolina Daffre Kaitlyn L. Oliver Kaitlyn L. Oliver Kylie Moore Kylie Moore Samuel Gazecki Samuel Gazecki Augustus Kram Mendelsohn Augustus Kram Mendelsohn Uriel Martinez Uriel Martinez Karen Gannon Natasha B. Lasko Natasha B. Lasko Edward F. Pace-Schott Edward F. Pace-Schott Edward F. Pace-Schott
author_sort	Dan Denis
title	Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity
title_short	Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity
title_full	Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity
title_fullStr	Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity
title_full_unstemmed	Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity
title_sort	sleep power spectral density and spindles in ptsd and their relationship to symptom severity
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/62e966d0c8b34bc1af29aaaa57f7f31f
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Sleep Power Spectral Density and Spindles in PTSD and Their Relationship to Symptom Severity

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