The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis

BACKGROUND AND OBJECTIVE: Acute proctitis is a common, disturbing side effect of pelvic irradiation that might interrupt treatment. To decrease or prevention of these side effects many drugs were used but no effective treatment was found. The aim of this study was to evaluate the efficacy of sucralf...

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Autores principales:	N Ahmadloo, L Kasraian, M Mohammadian Panah, SH Omidvari, A . Mosalaei
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	sucralfate pelvic radiotherapy proctitis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/62ea597b2c694c9e851abe590987acdb
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spelling	oai:doaj.org-article:62ea597b2c694c9e851abe590987acdb2021-11-10T09:02:52ZThe Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis1561-41072251-7170https://doaj.org/article/62ea597b2c694c9e851abe590987acdb2009-08-01T00:00:00Zhttp://jbums.org/article-1-3219-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Acute proctitis is a common, disturbing side effect of pelvic irradiation that might interrupt treatment. To decrease or prevention of these side effects many drugs were used but no effective treatment was found. The aim of this study was to evaluate the efficacy of sucralfate for possible reduction of radiation-induced lower GI toxicities.METHODS: In this clinical trial study 100 patients that required curative pelvic radiation therapy were randomly divided into two groups. Group one received 3g oral sucralfate and group two received placebo as control. All patients were given at least 50 Gy external-beam irradiation. Their bowel symptoms that include diarrhea, abdominal pain or distention, mucous or bloody discharge, obstruction or perforation were scored according to the RTOG/EORTC acute toxicity criteria. Desquamation and duration of treatment interruption were studied in both groups.FINDINGS: From cases, there were 49 cases in group one and 47 cases in group two and 4 cases were excluded from study. The two groups were statistically the same according to sex, age, anatomopathology and radiation therapy parameters. Comparing acute lower GI toxicities, desquamation and duration of treatment interruption, there were no statistically significant differences between the two groups. No acute lower GI toxicities were seen in 18 cases from group one and 10 cases from group two. No grade 4 lower GI toxicities were seen in patients.CONCLUSION: In our study, there was no clinical evidence that oral sucralfate ameliorates radiation-induced proctitis. Therefore, sucralfate as a routine prophylactic agent is not suggested in pelvic radiation therapy and further investigations are generally needed to find out the efficacy of sucralfate in radiation-induced GI toxicities.N AhmadlooL KasraianM Mohammadian PanahSH Omidvari,A . MosalaeiBabol University of Medical Sciencesarticlesucralfatepelvic radiotherapyproctitisMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 3, Pp 20-25 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	sucralfate pelvic radiotherapy proctitis Medicine R Medicine (General) R5-920
spellingShingle	sucralfate pelvic radiotherapy proctitis Medicine R Medicine (General) R5-920 N Ahmadloo L Kasraian M Mohammadian Panah SH Omidvari, A . Mosalaei The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis
description	BACKGROUND AND OBJECTIVE: Acute proctitis is a common, disturbing side effect of pelvic irradiation that might interrupt treatment. To decrease or prevention of these side effects many drugs were used but no effective treatment was found. The aim of this study was to evaluate the efficacy of sucralfate for possible reduction of radiation-induced lower GI toxicities.METHODS: In this clinical trial study 100 patients that required curative pelvic radiation therapy were randomly divided into two groups. Group one received 3g oral sucralfate and group two received placebo as control. All patients were given at least 50 Gy external-beam irradiation. Their bowel symptoms that include diarrhea, abdominal pain or distention, mucous or bloody discharge, obstruction or perforation were scored according to the RTOG/EORTC acute toxicity criteria. Desquamation and duration of treatment interruption were studied in both groups.FINDINGS: From cases, there were 49 cases in group one and 47 cases in group two and 4 cases were excluded from study. The two groups were statistically the same according to sex, age, anatomopathology and radiation therapy parameters. Comparing acute lower GI toxicities, desquamation and duration of treatment interruption, there were no statistically significant differences between the two groups. No acute lower GI toxicities were seen in 18 cases from group one and 10 cases from group two. No grade 4 lower GI toxicities were seen in patients.CONCLUSION: In our study, there was no clinical evidence that oral sucralfate ameliorates radiation-induced proctitis. Therefore, sucralfate as a routine prophylactic agent is not suggested in pelvic radiation therapy and further investigations are generally needed to find out the efficacy of sucralfate in radiation-induced GI toxicities.
format	article
author	N Ahmadloo L Kasraian M Mohammadian Panah SH Omidvari, A . Mosalaei
author_facet	N Ahmadloo L Kasraian M Mohammadian Panah SH Omidvari, A . Mosalaei
author_sort	N Ahmadloo
title	The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis
title_short	The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis
title_full	The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis
title_fullStr	The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis
title_full_unstemmed	The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis
title_sort	effect of sucralfate in prevention of radiation- induced acute proctitis
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/62ea597b2c694c9e851abe590987acdb
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The Effect of Sucralfate in Prevention of Radiation- Induced Acute Proctitis

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