Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets

Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets

Alpha-fetoprotein producing gastric carcinomas (AFPGC) are rare and aggressive. Here, the authors profile AFPGC tumours using whole exome sequencing, and find amplifications in CCNE1 and ERBB2 that are associated with poor outcomes but are potential therapeutic targets, as shown in patient-derived x...

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Autores principales: Jun Lu, Yongfeng Ding, Yanyan Chen, Junjie Jiang, Yiran Chen, Yingying Huang, Mengjie Wu, Chengzhi Li, Mei Kong, Wenyi Zhao, Haohao Wang, Jing Zhang, Zhongqi Li, Yimin Lu, Xiongfei Yu, Ketao Jin, Donghui Zhou, Tianhua Zhou, Fei Teng, Haibin Zhang, Zhan Zhou, Haiyong Wang, Lisong Teng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/62eaf54d85ae48668df58ac7963f12d5
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spelling oai:doaj.org-article:62eaf54d85ae48668df58ac7963f12d52021-12-02T17:12:16ZWhole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets10.1038/s41467-021-24170-02041-1723https://doaj.org/article/62eaf54d85ae48668df58ac7963f12d52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24170-0https://doaj.org/toc/2041-1723Alpha-fetoprotein producing gastric carcinomas (AFPGC) are rare and aggressive. Here, the authors profile AFPGC tumours using whole exome sequencing, and find amplifications in CCNE1 and ERBB2 that are associated with poor outcomes but are potential therapeutic targets, as shown in patient-derived xenografts.Jun LuYongfeng DingYanyan ChenJunjie JiangYiran ChenYingying HuangMengjie WuChengzhi LiMei KongWenyi ZhaoHaohao WangJing ZhangZhongqi LiYimin LuXiongfei YuKetao JinDonghui ZhouTianhua ZhouFei TengHaibin ZhangZhan ZhouHaiyong WangLisong TengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Lu
Yongfeng Ding
Yanyan Chen
Junjie Jiang
Yiran Chen
Yingying Huang
Mengjie Wu
Chengzhi Li
Mei Kong
Wenyi Zhao
Haohao Wang
Jing Zhang
Zhongqi Li
Yimin Lu
Xiongfei Yu
Ketao Jin
Donghui Zhou
Tianhua Zhou
Fei Teng
Haibin Zhang
Zhan Zhou
Haiyong Wang
Lisong Teng
Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
description Alpha-fetoprotein producing gastric carcinomas (AFPGC) are rare and aggressive. Here, the authors profile AFPGC tumours using whole exome sequencing, and find amplifications in CCNE1 and ERBB2 that are associated with poor outcomes but are potential therapeutic targets, as shown in patient-derived xenografts.
format article
author Jun Lu
Yongfeng Ding
Yanyan Chen
Junjie Jiang
Yiran Chen
Yingying Huang
Mengjie Wu
Chengzhi Li
Mei Kong
Wenyi Zhao
Haohao Wang
Jing Zhang
Zhongqi Li
Yimin Lu
Xiongfei Yu
Ketao Jin
Donghui Zhou
Tianhua Zhou
Fei Teng
Haibin Zhang
Zhan Zhou
Haiyong Wang
Lisong Teng
author_facet Jun Lu
Yongfeng Ding
Yanyan Chen
Junjie Jiang
Yiran Chen
Yingying Huang
Mengjie Wu
Chengzhi Li
Mei Kong
Wenyi Zhao
Haohao Wang
Jing Zhang
Zhongqi Li
Yimin Lu
Xiongfei Yu
Ketao Jin
Donghui Zhou
Tianhua Zhou
Fei Teng
Haibin Zhang
Zhan Zhou
Haiyong Wang
Lisong Teng
author_sort Jun Lu
title Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
title_short Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
title_full Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
title_fullStr Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
title_full_unstemmed Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
title_sort whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/62eaf54d85ae48668df58ac7963f12d5
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