Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets

Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets

Alpha-fetoprotein producing gastric carcinomas (AFPGC) are rare and aggressive. Here, the authors profile AFPGC tumours using whole exome sequencing, and find amplifications in CCNE1 and ERBB2 that are associated with poor outcomes but are potential therapeutic targets, as shown in patient-derived x...

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Main Authors: Jun Lu, Yongfeng Ding, Yanyan Chen, Junjie Jiang, Yiran Chen, Yingying Huang, Mengjie Wu, Chengzhi Li, Mei Kong, Wenyi Zhao, Haohao Wang, Jing Zhang, Zhongqi Li, Yimin Lu, Xiongfei Yu, Ketao Jin, Donghui Zhou, Tianhua Zhou, Fei Teng, Haibin Zhang, Zhan Zhou, Haiyong Wang, Lisong Teng
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/62eaf54d85ae48668df58ac7963f12d5
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https://doaj.org/article/62eaf54d85ae48668df58ac7963f12d5

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