Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection

Spores produced by Clostridioides difficile during infection are important for the recurrence of the disease. Here, Castro-Córdova et al. show that the spores gain entry into the intestinal mucosa via pathways dependent on host fibronectin and vitronectin, and spore entry inhibition leads to reduced...

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Autores principales:	Pablo Castro-Córdova, Paola Mora-Uribe, Rodrigo Reyes-Ramírez, Glenda Cofré-Araneda, Josué Orozco-Aguilar, Christian Brito-Silva, María José Mendoza-León, Sarah A. Kuehne, Nigel P. Minton, Marjorie Pizarro-Guajardo, Daniel Paredes-Sabja
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62ebad3827eb4925817d4a2de6d0326f
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spelling	oai:doaj.org-article:62ebad3827eb4925817d4a2de6d0326f2021-12-02T14:21:27ZEntry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection10.1038/s41467-021-21355-52041-1723https://doaj.org/article/62ebad3827eb4925817d4a2de6d0326f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21355-5https://doaj.org/toc/2041-1723Spores produced by Clostridioides difficile during infection are important for the recurrence of the disease. Here, Castro-Córdova et al. show that the spores gain entry into the intestinal mucosa via pathways dependent on host fibronectin and vitronectin, and spore entry inhibition leads to reduced recurrence of infection in a mouse model.Pablo Castro-CórdovaPaola Mora-UribeRodrigo Reyes-RamírezGlenda Cofré-AranedaJosué Orozco-AguilarChristian Brito-SilvaMaría José Mendoza-LeónSarah A. KuehneNigel P. MintonMarjorie Pizarro-GuajardoDaniel Paredes-SabjaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pablo Castro-Córdova Paola Mora-Uribe Rodrigo Reyes-Ramírez Glenda Cofré-Araneda Josué Orozco-Aguilar Christian Brito-Silva María José Mendoza-León Sarah A. Kuehne Nigel P. Minton Marjorie Pizarro-Guajardo Daniel Paredes-Sabja Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
description	Spores produced by Clostridioides difficile during infection are important for the recurrence of the disease. Here, Castro-Córdova et al. show that the spores gain entry into the intestinal mucosa via pathways dependent on host fibronectin and vitronectin, and spore entry inhibition leads to reduced recurrence of infection in a mouse model.
format	article
author	Pablo Castro-Córdova Paola Mora-Uribe Rodrigo Reyes-Ramírez Glenda Cofré-Araneda Josué Orozco-Aguilar Christian Brito-Silva María José Mendoza-León Sarah A. Kuehne Nigel P. Minton Marjorie Pizarro-Guajardo Daniel Paredes-Sabja
author_facet	Pablo Castro-Córdova Paola Mora-Uribe Rodrigo Reyes-Ramírez Glenda Cofré-Araneda Josué Orozco-Aguilar Christian Brito-Silva María José Mendoza-León Sarah A. Kuehne Nigel P. Minton Marjorie Pizarro-Guajardo Daniel Paredes-Sabja
author_sort	Pablo Castro-Córdova
title	Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
title_short	Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
title_full	Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
title_fullStr	Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
title_full_unstemmed	Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
title_sort	entry of spores into intestinal epithelial cells contributes to recurrence of clostridioides difficile infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/62ebad3827eb4925817d4a2de6d0326f
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Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection

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