Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.

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Autores principales: Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Xiaonan Xu, Zhihuang Hu, Le Zhang, Yi Yang, Xun Zhu, Heng Zhang, Jueheng Wu, Yan Huang, Jun Li, Musheng Zeng, Erwei Song, Yukai He, Li Zhang, Mengfeng Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/62ebaf9fb06e4953beda02cb7177db31
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spelling oai:doaj.org-article:62ebaf9fb06e4953beda02cb7177db312021-12-02T17:01:16ZSimultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC10.1038/ncomms158702041-1723https://doaj.org/article/62ebaf9fb06e4953beda02cb7177db312017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15870https://doaj.org/toc/2041-1723Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.Junchao CaiLishan FangYongbo HuangRong LiXiaonan XuZhihuang HuLe ZhangYi YangXun ZhuHeng ZhangJueheng WuYan HuangJun LiMusheng ZengErwei SongYukai HeLi ZhangMengfeng LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Junchao Cai
Lishan Fang
Yongbo Huang
Rong Li
Xiaonan Xu
Zhihuang Hu
Le Zhang
Yi Yang
Xun Zhu
Heng Zhang
Jueheng Wu
Yan Huang
Jun Li
Musheng Zeng
Erwei Song
Yukai He
Li Zhang
Mengfeng Li
Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
description Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.
format article
author Junchao Cai
Lishan Fang
Yongbo Huang
Rong Li
Xiaonan Xu
Zhihuang Hu
Le Zhang
Yi Yang
Xun Zhu
Heng Zhang
Jueheng Wu
Yan Huang
Jun Li
Musheng Zeng
Erwei Song
Yukai He
Li Zhang
Mengfeng Li
author_facet Junchao Cai
Lishan Fang
Yongbo Huang
Rong Li
Xiaonan Xu
Zhihuang Hu
Le Zhang
Yi Yang
Xun Zhu
Heng Zhang
Jueheng Wu
Yan Huang
Jun Li
Musheng Zeng
Erwei Song
Yukai He
Li Zhang
Mengfeng Li
author_sort Junchao Cai
title Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
title_short Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
title_full Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
title_fullStr Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
title_full_unstemmed Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
title_sort simultaneous overactivation of wnt/β-catenin and tgfβ signalling by mir-128-3p confers chemoresistance-associated metastasis in nsclc
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/62ebaf9fb06e4953beda02cb7177db31
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