Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.

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Auteurs principaux: Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Xiaonan Xu, Zhihuang Hu, Le Zhang, Yi Yang, Xun Zhu, Heng Zhang, Jueheng Wu, Yan Huang, Jun Li, Musheng Zeng, Erwei Song, Yukai He, Li Zhang, Mengfeng Li
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/62ebaf9fb06e4953beda02cb7177db31
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https://doaj.org/article/62ebaf9fb06e4953beda02cb7177db31

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