Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

The inhibitory receptors PD-1, Tim-3 and Lag-3 act as negative feedback regulators of T cell responses. Here the authors improve CAR T cell antitumor efficacy by triple knockdown of these receptors, show it requires CD56, and correlate CD56-mediated homophilic cell interactions with CAR T cell effic...

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Autores principales:	Fan Zou, Lijuan Lu, Jun Liu, Baijin Xia, Wanying Zhang, Qifei Hu, Weiwei Liu, Yiwen Zhang, Yingtong Lin, Shuliang Jing, Mei Huang, Bifen Huang, Bingfeng Liu, Hui Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62ecd82ea5c54588adc2d3e0f20f49a1
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spelling	oai:doaj.org-article:62ecd82ea5c54588adc2d3e0f20f49a12021-12-02T14:39:55ZEngineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD5610.1038/s41467-019-11893-42041-1723https://doaj.org/article/62ecd82ea5c54588adc2d3e0f20f49a12019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11893-4https://doaj.org/toc/2041-1723The inhibitory receptors PD-1, Tim-3 and Lag-3 act as negative feedback regulators of T cell responses. Here the authors improve CAR T cell antitumor efficacy by triple knockdown of these receptors, show it requires CD56, and correlate CD56-mediated homophilic cell interactions with CAR T cell efficacy.Fan ZouLijuan LuJun LiuBaijin XiaWanying ZhangQifei HuWeiwei LiuYiwen ZhangYingtong LinShuliang JingMei HuangBifen HuangBingfeng LiuHui ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fan Zou Lijuan Lu Jun Liu Baijin Xia Wanying Zhang Qifei Hu Weiwei Liu Yiwen Zhang Yingtong Lin Shuliang Jing Mei Huang Bifen Huang Bingfeng Liu Hui Zhang Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
description	The inhibitory receptors PD-1, Tim-3 and Lag-3 act as negative feedback regulators of T cell responses. Here the authors improve CAR T cell antitumor efficacy by triple knockdown of these receptors, show it requires CD56, and correlate CD56-mediated homophilic cell interactions with CAR T cell efficacy.
format	article
author	Fan Zou Lijuan Lu Jun Liu Baijin Xia Wanying Zhang Qifei Hu Weiwei Liu Yiwen Zhang Yingtong Lin Shuliang Jing Mei Huang Bifen Huang Bingfeng Liu Hui Zhang
author_facet	Fan Zou Lijuan Lu Jun Liu Baijin Xia Wanying Zhang Qifei Hu Weiwei Liu Yiwen Zhang Yingtong Lin Shuliang Jing Mei Huang Bifen Huang Bingfeng Liu Hui Zhang
author_sort	Fan Zou
title	Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
title_short	Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
title_full	Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
title_fullStr	Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
title_full_unstemmed	Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
title_sort	engineered triple inhibitory receptor resistance improves anti-tumor car-t cell performance via cd56
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/62ecd82ea5c54588adc2d3e0f20f49a1
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Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

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