Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

The inhibitory receptors PD-1, Tim-3 and Lag-3 act as negative feedback regulators of T cell responses. Here the authors improve CAR T cell antitumor efficacy by triple knockdown of these receptors, show it requires CD56, and correlate CD56-mediated homophilic cell interactions with CAR T cell effic...

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Autores principales: Fan Zou, Lijuan Lu, Jun Liu, Baijin Xia, Wanying Zhang, Qifei Hu, Weiwei Liu, Yiwen Zhang, Yingtong Lin, Shuliang Jing, Mei Huang, Bifen Huang, Bingfeng Liu, Hui Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/62ecd82ea5c54588adc2d3e0f20f49a1
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