Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.

Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogen...

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Autores principales:	Leandra Barcelos Figueiredo, Tetsu Sakamoto, Luiz Felipe Leomil Coelho, Eliseu Soares de Oliveira Rocha, Marcela Menezes Gomes Cota, Gustavo Portela Ferreira, Jaquelline Germano de Oliveira, Erna Geessien Kroon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62eda789a6e346e687ce20959e0bdde3
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spelling	oai:doaj.org-article:62eda789a6e346e687ce20959e0bdde32021-11-25T06:04:35ZDengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.1932-620310.1371/journal.pone.0104516https://doaj.org/article/62eda789a6e346e687ce20959e0bdde32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25127366/?tool=EBIhttps://doaj.org/toc/1932-6203Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogenetic studies. DENV-2, which was isolated from dengue fever patients during an outbreak in Piaui, Brazil in 2006/2007 was analyzed by sequencing the envelope (E) gene. The results indicated a high similarity among the isolated viruses, as well as to other DENV-2 from Brazil, Central America and South America. A phylogenetic and phylogeographic analysis based on DENV-2E gene sequences revealed that these viruses are grouped together with viruses of the American-Asian genotype in two distinct lineages. Our results demonstrate the co-circulation of two American-Asian genotype lineages in northeast Brazil. Moreover, we reveal that DENV-2 lineage 2 was detected in Piauí before it disseminated to other Brazilian states and South American countries, indicating the existence of a new dissemination route that has not been previously described.Leandra Barcelos FigueiredoTetsu SakamotoLuiz Felipe Leomil CoelhoEliseu Soares de Oliveira RochaMarcela Menezes Gomes CotaGustavo Portela FerreiraJaquelline Germano de OliveiraErna Geessien KroonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104516 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leandra Barcelos Figueiredo Tetsu Sakamoto Luiz Felipe Leomil Coelho Eliseu Soares de Oliveira Rocha Marcela Menezes Gomes Cota Gustavo Portela Ferreira Jaquelline Germano de Oliveira Erna Geessien Kroon Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.
description	Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogenetic studies. DENV-2, which was isolated from dengue fever patients during an outbreak in Piaui, Brazil in 2006/2007 was analyzed by sequencing the envelope (E) gene. The results indicated a high similarity among the isolated viruses, as well as to other DENV-2 from Brazil, Central America and South America. A phylogenetic and phylogeographic analysis based on DENV-2E gene sequences revealed that these viruses are grouped together with viruses of the American-Asian genotype in two distinct lineages. Our results demonstrate the co-circulation of two American-Asian genotype lineages in northeast Brazil. Moreover, we reveal that DENV-2 lineage 2 was detected in Piauí before it disseminated to other Brazilian states and South American countries, indicating the existence of a new dissemination route that has not been previously described.
format	article
author	Leandra Barcelos Figueiredo Tetsu Sakamoto Luiz Felipe Leomil Coelho Eliseu Soares de Oliveira Rocha Marcela Menezes Gomes Cota Gustavo Portela Ferreira Jaquelline Germano de Oliveira Erna Geessien Kroon
author_facet	Leandra Barcelos Figueiredo Tetsu Sakamoto Luiz Felipe Leomil Coelho Eliseu Soares de Oliveira Rocha Marcela Menezes Gomes Cota Gustavo Portela Ferreira Jaquelline Germano de Oliveira Erna Geessien Kroon
author_sort	Leandra Barcelos Figueiredo
title	Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.
title_short	Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.
title_full	Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.
title_fullStr	Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.
title_full_unstemmed	Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.
title_sort	dengue virus 2 american-asian genotype identified during the 2006/2007 outbreak in piauí, brazil reveals a caribbean route of introduction and dissemination of dengue virus in brazil.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/62eda789a6e346e687ce20959e0bdde3
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Dengue virus 2 American-Asian genotype identified during the 2006/2007 outbreak in Piauí, Brazil reveals a Caribbean route of introduction and dissemination of dengue virus in Brazil.

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