An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma

Immunogenic cell death (ICD) has been classified as a form of regulated cell death (RCD) that is sufficient to activate an adaptive immune response. Accumulating evidence has demonstrated the ability of ICD to reshape the tumor immune microenvironment through the emission of danger signals or DAMPs,...

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Autores principales:	Xinwen Wang, Shouwu Wu, Feng Liu, Dianshan Ke, Xinwu Wang, Dinglong Pan, Weifeng Xu, Ling Zhou, Weidong He
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	immunogenic cell death head and neck squamous cell carcinoma prognosis tumor microenvionment immunotherapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/62f2e2116a6544e68bfacb37349e2d60
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spelling	oai:doaj.org-article:62f2e2116a6544e68bfacb37349e2d602021-11-19T07:53:33ZAn Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma1664-322410.3389/fimmu.2021.781466https://doaj.org/article/62f2e2116a6544e68bfacb37349e2d602021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.781466/fullhttps://doaj.org/toc/1664-3224Immunogenic cell death (ICD) has been classified as a form of regulated cell death (RCD) that is sufficient to activate an adaptive immune response. Accumulating evidence has demonstrated the ability of ICD to reshape the tumor immune microenvironment through the emission of danger signals or DAMPs, which may contribute to the immunotherapy. Currently, identification of ICD-associated biomarkers that stratify patients according to their benefit from ICD immunotherapy would be of great advantage. Here, we identified two ICD-associated subtypes by consensus clustering. ICD-high subtype was associated with the favorable clinical outcomes, abundant immune cell infiltration, and high activity of immune response signaling. Besides, we established and validated an ICD-related prognostic model that predicted the survival of HNSCC and was associated with tumor immune microenvironment. In conclusion, we established a new classification system of HNSCC based on ICD signatures. This stratification had significant clinical outcomes for estimating prognosis, as well as the immunotherapy of HNSCC patientsXinwen WangShouwu WuFeng LiuDianshan KeXinwu WangDinglong PanWeifeng XuLing ZhouWeidong HeFrontiers Media S.A.articleimmunogenic cell deathhead and neck squamous cell carcinomaprognosistumor microenvionmentimmunotherapyImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunogenic cell death head and neck squamous cell carcinoma prognosis tumor microenvionment immunotherapy Immunologic diseases. Allergy RC581-607
spellingShingle	immunogenic cell death head and neck squamous cell carcinoma prognosis tumor microenvionment immunotherapy Immunologic diseases. Allergy RC581-607 Xinwen Wang Shouwu Wu Feng Liu Dianshan Ke Xinwu Wang Dinglong Pan Weifeng Xu Ling Zhou Weidong He An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma
description	Immunogenic cell death (ICD) has been classified as a form of regulated cell death (RCD) that is sufficient to activate an adaptive immune response. Accumulating evidence has demonstrated the ability of ICD to reshape the tumor immune microenvironment through the emission of danger signals or DAMPs, which may contribute to the immunotherapy. Currently, identification of ICD-associated biomarkers that stratify patients according to their benefit from ICD immunotherapy would be of great advantage. Here, we identified two ICD-associated subtypes by consensus clustering. ICD-high subtype was associated with the favorable clinical outcomes, abundant immune cell infiltration, and high activity of immune response signaling. Besides, we established and validated an ICD-related prognostic model that predicted the survival of HNSCC and was associated with tumor immune microenvironment. In conclusion, we established a new classification system of HNSCC based on ICD signatures. This stratification had significant clinical outcomes for estimating prognosis, as well as the immunotherapy of HNSCC patients
format	article
author	Xinwen Wang Shouwu Wu Feng Liu Dianshan Ke Xinwu Wang Dinglong Pan Weifeng Xu Ling Zhou Weidong He
author_facet	Xinwen Wang Shouwu Wu Feng Liu Dianshan Ke Xinwu Wang Dinglong Pan Weifeng Xu Ling Zhou Weidong He
author_sort	Xinwen Wang
title	An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma
title_short	An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma
title_full	An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma
title_fullStr	An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed	An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma
title_sort	immunogenic cell death-related classification predicts prognosis and response to immunotherapy in head and neck squamous cell carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/62f2e2116a6544e68bfacb37349e2d60
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An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Head and Neck Squamous Cell Carcinoma

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