Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes

Xiaoyan Sun, Lingzi Liu, Hui Zou, Caixia Yao, Zhengyu Yan, Baofen Ye Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, Jiangsu 210009, People’s Republic of ChinaCorrespondence: Baofen YeKey Laboratory of Biomedical Functional Ma...

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Autores principales:	Sun X, Liu L, Zou H, Yao C, Yan Z, Ye B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	drug delivery; microparticles; color change; graphene oxide photothermal effect. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/62f46af5a3a0488cb8ee6df3a9c1c88c
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spelling	oai:doaj.org-article:62f46af5a3a0488cb8ee6df3a9c1c88c2021-12-02T12:11:57ZIntelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes1178-2013https://doaj.org/article/62f46af5a3a0488cb8ee6df3a9c1c88c2020-07-01T00:00:00Zhttps://www.dovepress.com/intelligent-drug-delivery-microparticles-with-visual-stimuli-responsiv-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaoyan Sun, Lingzi Liu, Hui Zou, Caixia Yao, Zhengyu Yan, Baofen Ye Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, Jiangsu 210009, People’s Republic of ChinaCorrespondence: Baofen YeKey Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 13951725591Email baofen_ye@163.comBackground: Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development. However, some problems remain to be solved, such as limited stimuli, visual-monitoring.Aim: To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.Materials and Methods: Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template. The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope. During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope. The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values. Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.Results: A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color. The FITC-dextran was uniformly encapsulated in the particles by using 0.2 wt% sodium alginate. The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release. With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively. The drug release quantity can be predicted by the structural color of microparticles.Conclusion: The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.Keywords: drug delivery, microparticles, color change, graphene oxide, photothermal effectSun XLiu LZou HYao CYan ZYe BDove Medical Pressarticledrug delivery; microparticles; color change; graphene oxidephotothermal effect.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 4959-4967 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery; microparticles; color change; graphene oxide photothermal effect. Medicine (General) R5-920
spellingShingle	drug delivery; microparticles; color change; graphene oxide photothermal effect. Medicine (General) R5-920 Sun X Liu L Zou H Yao C Yan Z Ye B Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes
description	Xiaoyan Sun, Lingzi Liu, Hui Zou, Caixia Yao, Zhengyu Yan, Baofen Ye Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, Jiangsu 210009, People’s Republic of ChinaCorrespondence: Baofen YeKey Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 13951725591Email baofen_ye@163.comBackground: Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development. However, some problems remain to be solved, such as limited stimuli, visual-monitoring.Aim: To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.Materials and Methods: Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template. The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope. During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope. The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values. Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.Results: A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color. The FITC-dextran was uniformly encapsulated in the particles by using 0.2 wt% sodium alginate. The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release. With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively. The drug release quantity can be predicted by the structural color of microparticles.Conclusion: The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.Keywords: drug delivery, microparticles, color change, graphene oxide, photothermal effect
format	article
author	Sun X Liu L Zou H Yao C Yan Z Ye B
author_facet	Sun X Liu L Zou H Yao C Yan Z Ye B
author_sort	Sun X
title	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes
title_short	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes
title_full	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes
title_fullStr	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes
title_full_unstemmed	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes
title_sort	intelligent drug delivery microparticles with visual stimuli-responsive structural color changes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/62f46af5a3a0488cb8ee6df3a9c1c88c
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Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes

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