IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.
While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully underst...
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Public Library of Science (PLoS)
2021
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oai:doaj.org-article:62f4a8a367f34005a027aa1979cbb21d2021-12-02T20:16:19ZIFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.1932-620310.1371/journal.pone.0260204https://doaj.org/article/62f4a8a367f34005a027aa1979cbb21d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260204https://doaj.org/toc/1932-6203While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully understood. We found that IFNγ decreases the expression of growth factor independent-1 transcriptional repressor (GFI1) in Th2 cells, resulting in the inhibition of Th2 cell proliferation. The deletion of the Gfi1 gene in Th2 cells results in the failure of their proliferation, accompanied by an impaired cell cycle progression. In contrast, the enforced expression of GFI1 restores the defective Th2 cell proliferation, even in the presence of IFNγ. These results demonstrate that GFI1 is a key molecule in the IFNγ-mediated inhibition of Th2 cell proliferation.Murshed H SarkarRyoji YagiYukihiro EndoRyo Koyama-NasuYangsong WangIchita HasegawaToshihiro ItoIlkka S JunttilaJinfang ZhuMotoko Y KimuraToshinori NakayamaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260204 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Murshed H Sarkar Ryoji Yagi Yukihiro Endo Ryo Koyama-Nasu Yangsong Wang Ichita Hasegawa Toshihiro Ito Ilkka S Junttila Jinfang Zhu Motoko Y Kimura Toshinori Nakayama IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| description |
While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2 cell proliferation is still not fully understood. We found that IFNγ decreases the expression of growth factor independent-1 transcriptional repressor (GFI1) in Th2 cells, resulting in the inhibition of Th2 cell proliferation. The deletion of the Gfi1 gene in Th2 cells results in the failure of their proliferation, accompanied by an impaired cell cycle progression. In contrast, the enforced expression of GFI1 restores the defective Th2 cell proliferation, even in the presence of IFNγ. These results demonstrate that GFI1 is a key molecule in the IFNγ-mediated inhibition of Th2 cell proliferation. |
| format |
article |
| author |
Murshed H Sarkar Ryoji Yagi Yukihiro Endo Ryo Koyama-Nasu Yangsong Wang Ichita Hasegawa Toshihiro Ito Ilkka S Junttila Jinfang Zhu Motoko Y Kimura Toshinori Nakayama |
| author_facet |
Murshed H Sarkar Ryoji Yagi Yukihiro Endo Ryo Koyama-Nasu Yangsong Wang Ichita Hasegawa Toshihiro Ito Ilkka S Junttila Jinfang Zhu Motoko Y Kimura Toshinori Nakayama |
| author_sort |
Murshed H Sarkar |
| title |
IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_short |
IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_full |
IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_fullStr |
IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_full_unstemmed |
IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. |
| title_sort |
ifnγ suppresses the expression of gfi1 and thereby inhibits th2 cell proliferation. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/62f4a8a367f34005a027aa1979cbb21d |
| work_keys_str_mv |
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