The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.

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Autores principales:	Mariam H. Orme, Gianmaria Liccardi, Nina Moderau, Rebecca Feltham, Sidonie Wicky-John, Tencho Tenev, Lior Aram, Rebecca Wilson, Katiuscia Bianchi, Otto Morris, Celia Monteiro Domingues, David Robertson, Meghana Tare, Alexander Wepf, David Williams, Andreas Bergmann, Matthias Gstaiger, Eli Arama, Paulo S. Ribeiro, Pascal Meier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62f4afcc0d684d22bc73279b49748e22
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spelling	oai:doaj.org-article:62f4afcc0d684d22bc73279b49748e222021-12-02T14:39:30ZThe unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles10.1038/ncomms109722041-1723https://doaj.org/article/62f4afcc0d684d22bc73279b49748e222016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10972https://doaj.org/toc/2041-1723In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.Mariam H. OrmeGianmaria LiccardiNina ModerauRebecca FelthamSidonie Wicky-JohnTencho TenevLior AramRebecca WilsonKatiuscia BianchiOtto MorrisCelia Monteiro DominguesDavid RobertsonMeghana TareAlexander WepfDavid WilliamsAndreas BergmannMatthias GstaigerEli AramaPaulo S. RibeiroPascal MeierNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariam H. Orme Gianmaria Liccardi Nina Moderau Rebecca Feltham Sidonie Wicky-John Tencho Tenev Lior Aram Rebecca Wilson Katiuscia Bianchi Otto Morris Celia Monteiro Domingues David Robertson Meghana Tare Alexander Wepf David Williams Andreas Bergmann Matthias Gstaiger Eli Arama Paulo S. Ribeiro Pascal Meier The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
description	In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.
format	article
author	Mariam H. Orme Gianmaria Liccardi Nina Moderau Rebecca Feltham Sidonie Wicky-John Tencho Tenev Lior Aram Rebecca Wilson Katiuscia Bianchi Otto Morris Celia Monteiro Domingues David Robertson Meghana Tare Alexander Wepf David Williams Andreas Bergmann Matthias Gstaiger Eli Arama Paulo S. Ribeiro Pascal Meier
author_facet	Mariam H. Orme Gianmaria Liccardi Nina Moderau Rebecca Feltham Sidonie Wicky-John Tencho Tenev Lior Aram Rebecca Wilson Katiuscia Bianchi Otto Morris Celia Monteiro Domingues David Robertson Meghana Tare Alexander Wepf David Williams Andreas Bergmann Matthias Gstaiger Eli Arama Paulo S. Ribeiro Pascal Meier
author_sort	Mariam H. Orme
title	The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
title_short	The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
title_full	The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
title_fullStr	The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
title_full_unstemmed	The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
title_sort	unconventional myosin crinkled and its mammalian orthologue myo7a regulate caspases in their signalling roles
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/62f4afcc0d684d22bc73279b49748e22
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The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

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